Flavor ingredient regulatory record
1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one
1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one is a ketone in the fruity family, FEMA GRAS under FEMA number 4721 (CAS 1186004-10-3). Its odor is sweet, floral, fruity, slightly spicy.
- FEMA
- 4721
- CAS
- 1186004-10-3
- JECFA
- 2158
- Formula
- C14H13NO2
GRAS status: FEMA GRAS, publication 25. Recorded by FDA in the Substances Added to Food inventory under CAS 1186004-10-3.
Structure
Identity
Also known as: 1-(2-hydroxyphenyl)-3-(pyridine-4-yl)propan-1-one, 1-(2-hydroxyphenyl)-3-(4-pyridinyl)-1-propanone, 1-propanone, 1-(2-hydroxyphenyl)-3-(4-pyridinyl)-, 1-(2-hydroxyphenyl)-3-pyridin-4-ylpropan-1-one.
Can 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one is FEMA GRAS under FEMA number 4721. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2158, evaluated at the 76th meeting in 2012. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, floral, fruity, slightly spicy.
Where it is used
1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one is used in beverage, confection, flavoring, bakery and desserts, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 1-(2-Hydroxy-4-methoxyphenyl)-3-(pyridin-2-yl)propan-1-one | 4723 | 86% | Not determined |
| Phenethyl salicylate | 2868 | 82% | In nature |
| Benzyl salicylate | 2151 | 81% | In nature |
| Phenyl salicylate | 3960 | 72% | Not determined |
| Phenethyl phenylacetate | 2866 | 66% | In nature |
More ketones in this index
Epoxy oxophorone · Acetoin propyleneglycol ketal · 4-Hexen-3-one · 2-Octen-4-one · 3-Decen-2-one · Vanillylidene acetone
1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one FAQ
Is 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one on the FEMA GRAS list?
It is. FEMA number 4721 covers 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one?
The FEMA number for 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one is 4721 and its CAS registry number is 1186004-10-3. Its flavor category is fruity.
What is 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one used for?
1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one is described as sweet, floral, fruity, slightly spicy. It shows up in beverage, confection, flavoring, bakery and desserts.
What did JECFA conclude about 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one?
JECFA evaluated 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one at the 76th meeting in 2012 under JECFA number 2158. The panel concluded: no safety concern at current levels of intake.
Is 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one approved in the EU?
No EU FL number is on file for 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one. It has a JECFA evaluation (JECFA 2158), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 1-(2-HYDROXYPHENYL)-3-(PYRIDIN-4-YL)PROPAN-1-ONE under CAS 1186004-10-3 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.