Insights
Working notes, technical takes, and field reports from building Ambrose.
September 14, 2026 · By Will Pemble
EU flavoring law has two chemical group schemes: the 34 groups in Regulation 1565/2000 and the 17 FL number prefixes in the Union list. They do not line up.
#EU Union List #FL number #chemical groups #Regulation (EC) No 1334/2008 #Regulation (EC) No 1565/2000 #EFSA
September 14, 2026 · By Will Pemble
A TSCA PMN flag marks a commenced premanufacture notice substance, an existing chemical you do not file a PMN for. About 52% have no public CAS number.
#TSCA #EPA #PMN #TSCA Inventory #40 CFR 720
September 14, 2026 · By Will Pemble
A TSCA S flag means a significant new use rule applies. A listed, active substance can still need a notice to EPA 90 days before the new use begins.
#TSCA #EPA #SNUR #TSCA Inventory #40 CFR 721
September 14, 2026 · By Will Pemble
XU marks a substance fully exempt from TSCA Chemical Data Reporting. The exemption belongs to the substance rather than to you, and it can lapse.
#TSCA #EPA #TSCA Inventory #Chemical Data Reporting #40 CFR 711
September 14, 2026 · By Will Pemble
About half the TSCA Inventory is inactive. Making one again takes a Notice of Activity Form B first, and the rule's 90 days is not a waiting period.
#TSCA #EPA #TSCA Inventory #chemical regulation #40 CFR 710
September 13, 2026 · By Will Pemble
An FL number identifies a flavoring substance in the EU. What the Union list holds, the two defaults hiding in its columns, and why the 2012 text misleads.
#FLAVIS #EU #flavourings #Regulation 1334/2008 #flavor regulation
September 13, 2026 · By Will Pemble
21 CFR 172.510 permits 130 botanicals as natural flavorings and attaches a condition to 31. What the conditions mean, and why wormwood covers a whole genus.
#21 CFR #FDA #botanicals #natural flavor #flavor regulation
September 12, 2026 · By Will Pemble
21 CFR 172.515 lists more than 700 synthetic flavoring substances FDA allows in food. How it differs from 182.60, and the six FDA removed in 2018.
#21 CFR #FDA #food additives #flavor regulation #FEMA GRAS
July 18, 2026 · By Will Pemble
How to file a GRAS notice with the FDA: the seven parts under 21 CFR 170.225 to 170.255, how to submit, the 180-day review, and the GRAS Notice Inventory.
#gras-notification #fda #regulatory #compliance #gras-notice
July 18, 2026 · By Will Pemble
The full 21 CFR 101.22(a)(3) natural flavor definition, the (i) rules for when a label must say flavored or artificially flavored, and what (j) requires.
#natural-flavor #artificial-flavor #21-cfr-101-22 #labeling #regulatory
July 18, 2026 · By Will Pemble
FEMA GRAS means the FEMA Expert Panel has concluded a flavor ingredient is Generally Recognized As Safe for its intended use. Search any FEMA number for free.
#fema-gras #regulatory #compliance #flavor-ingredients #fda
July 18, 2026 · By Will Pemble
An AI flavor formulator turns a brief into a first-draft formula for a flavorist to refine. How it differs from a chatbot, and how to tell a good one.
#ai #flavor-formulation #flavor-chemistry #r-and-d #aroma-chemicals
July 14, 2026 · By Will Pemble
What your current stack costs in dollars and chemist-weeks, with an interactive calculator so you can see it for your own portfolio.
#r-and-d #formulation #regulatory #labeling #cost-benchmarks #flavor #fragrance #brewery #coffee-tea #personal-care
Twice-monthly. AI in the flavor and fragrance industry. No fluff.