Flavor ingredient regulatory record
1-Cyclopropanemethyl-4-methoxybenzene
1-Cyclopropanemethyl-4-methoxybenzene is a phenol in the fruity family, FEMA GRAS under FEMA number 4759 (CAS 16510-27-3).
- FEMA
- 4759
- CAS
- 16510-27-3
- JECFA
- 2190
- Formula
- C11H14O
GRAS status: FEMA GRAS. Source: FEMA Flavor Ingredient Library.
Structure
Identity
Also known as: Benzene, 1-(cyclopropylmethyl)-4-methoxy-, Anisole, p-(cyclopropylmethyl)-, 1-(Cyclopropylmethyl)-4-methoxybenzene, Toscanol, (4-Methoxybenzyl)cyclopropane, 1-(cyclopropylmethyl)-4-methoxybenzene, benzene, 1-(cyclopropylmethyl)-4-methoxy-, anisole, p-(cyclopropylmethyl)-, sassafras acetate, anisole, p-(cyclopropylmethyl), 1-cyclopropylmethyl-4-methoxybenzene, 1-cyclopropylmethyl-4-methoxy-benzene.
Can 1-Cyclopropanemethyl-4-methoxybenzene be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
1-Cyclopropanemethyl-4-methoxybenzene is FEMA GRAS under FEMA number 4759. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 1-Cyclopropanemethyl-4-methoxybenzene. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2190.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 1-Cyclopropanemethyl-4-methoxybenzene appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 16510-27-3, where EPA names it Benzene, 1-(cyclopropylmethyl)-4-methoxy-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA regulatory flags
| Flag | EPA definition | What it obliges |
|---|---|---|
| PMN | Indicates a commenced PMN substance. | Nothing new. The substance already went through premanufacture review and someone filed a notice of commencement, which is why it is on the Inventory. It is an existing chemical and needs no new premanufacture notice. Read more |
PMN does not establish: The flag records how the substance arrived, not what may be done with it. Check the flags beside it.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Taste: Sweet, slightly spicy, complex.
Where it is used
1-Cyclopropanemethyl-4-methoxybenzene is used in beverage, confection, flavoring agents and baked goods, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 1-Cyclopropanemethyl-4-methoxybenzene by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| p-Propylanisole | 2930 | 74% | In nature |
| 2,3-Epoxyheptanal | 4658 | 66% | Not determined |
More phenols in this index
4-Ethyl-2,6-dimethoxyphenol · p-Propylanisole · 1-Methoxy-4-methylbenzene · 1-Methyl-3-methoxy-4-isopropylbenzene · 1-Methoxy-2-methylbenzene · 4-Methyl-2,6-dimethoxyphenol
1-Cyclopropanemethyl-4-methoxybenzene FAQ
Does 1-Cyclopropanemethyl-4-methoxybenzene have FEMA GRAS status?
1-Cyclopropanemethyl-4-methoxybenzene holds FEMA GRAS status under FEMA number 4759. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite 1-Cyclopropanemethyl-4-methoxybenzene by FEMA or CAS number?
Cite 1-Cyclopropanemethyl-4-methoxybenzene as FEMA 4759 or CAS 16510-27-3; both point to the same entry. Its flavor category is fruity.
What did JECFA conclude about 1-Cyclopropanemethyl-4-methoxybenzene?
JECFA evaluated 1-Cyclopropanemethyl-4-methoxybenzene under JECFA number 2190.
Is 1-Cyclopropanemethyl-4-methoxybenzene approved in the EU?
No EU FL number is on file for 1-Cyclopropanemethyl-4-methoxybenzene. It has a JECFA evaluation (JECFA 2190), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Check 1-Cyclopropanemethyl-4-methoxybenzene in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The FEMA number and GRAS status on this page name a conclusion reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States. FDA does not list this substance by FEMA number in its Substances Added to Food inventory. Its identity is attested by EPA TSCA Chemical Substance Inventory, matched on CAS 16510-27-3.
FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.