Flavor ingredient regulatory record
2-Amino-2-deoxy-poly-D-glucosamine
2-Amino-2-deoxy-poly-D-glucosamine is an amino sugar in the sweet family, FEMA GRAS under FEMA number 4946 (CAS 9012-76-4). Its odor is sweet, syrupy, caramel, mild, earthy.
- FEMA
- 4946
- CAS
- 9012-76-4
GRAS status: FEMA GRAS. Source: FEMA Flavor Ingredient Library.
Structure
Under review
The structure for 2-Amino-2-deoxy-poly-D-glucosamine is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: Chitosan, Deacetylchitin, Chitin, N-deacetyl-, Chitan, N-acetyl-, Kytex H, Flonac N, Kytex M, DAC 70, Chicol, Kimitsu Chitosan F 2, Kimitsu Chitosan F, Kimitsu Chitosan M.
Can 2-Amino-2-deoxy-poly-D-glucosamine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2-Amino-2-deoxy-poly-D-glucosamine is FEMA GRAS under FEMA number 4946. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 2-Amino-2-deoxy-poly-D-glucosamine. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
2-Amino-2-deoxy-poly-D-glucosamine has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 2-Amino-2-deoxy-poly-D-glucosamine appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 9012-76-4, where EPA names it Chitosan.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA regulatory flags
| Flag | EPA definition | What it obliges |
|---|---|---|
| FRI | Indicates a polymeric substance containing no free-radical initiator in its Inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. | Nothing directly. It widens what the listing covers, so a polymer made with a different initiator is still the listed substance rather than a new one. |
| XU | Indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711). | Nothing, for this substance, in the CDR census. The exemption belongs to the chemical and not to your company, so every other substance you make above the reporting threshold still counts. Read more |
XU does not establish: Says nothing about hazard, about commercial activity status, or about obligations under any other part of TSCA.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, syrupy, caramel, mild, earthy.
Taste: Sweet, mild, umami.
Where it is used
2-Amino-2-deoxy-poly-D-glucosamine is used in beverage, confection, nutritional supplements and food additives, typically as a sweet note.
2-Amino-2-deoxy-poly-D-glucosamine FAQ
Is 2-Amino-2-deoxy-poly-D-glucosamine on the FEMA GRAS list?
It is. FEMA number 4946 covers 2-Amino-2-deoxy-poly-D-glucosamine. It is also codified at 21 CFR 172.515.
What is the FEMA number for 2-Amino-2-deoxy-poly-D-glucosamine?
The FEMA number for 2-Amino-2-deoxy-poly-D-glucosamine is 4946 and its CAS registry number is 9012-76-4. FEMA files it in the sweet flavor category.
What is 2-Amino-2-deoxy-poly-D-glucosamine used for?
2-Amino-2-deoxy-poly-D-glucosamine is described as sweet, syrupy, caramel, mild, earthy. On the palate it is sweet, mild, umami. It shows up in beverage, confection, nutritional supplements and food additives.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The FEMA number and GRAS status on this page name a conclusion reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States. FDA does not list this substance by FEMA number in its Substances Added to Food inventory. Its identity is attested by EPA TSCA Chemical Substance Inventory, matched on CAS 9012-76-4.
FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.