Flavor ingredient regulatory record
2-Ethylthiophenol
2-Ethylthiophenol is a thiol in the sulfur family, FEMA GRAS under FEMA number 3345 (CAS 4500-58-7). Its odor is pungent, sulfurous, earthy, musty.
- FEMA
- 3345
- CAS
- 4500-58-7
- JECFA
- 529
- EU FL
- 12.054
- Formula
- C8H10S
GRAS status: FEMA GRAS, publication 6. Recorded by FDA in the Substances Added to Food inventory under CAS 4500-58-7.
Structure
Identity
Also known as: Benzenethiol, 2-ethyl-, Benzenethiol, o-ethyl-, 2-Ethylbenzenethiol, o-Ethylbenzenethiol, 2-Ethylbenzothiol, 2-ethylbenzenethiol, benzenethiol, 2-ethyl-, o-ethylbenzenethiol, 2-ethylbenzene-1-thiol, benzenethiol, o-ethyl-, 2-ethylphenylmercaptan, ethylbenzenethiol, o-.
Can 2-Ethylthiophenol be labeled natural?
Nature makes 2-Ethylthiophenol, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial 2-Ethylthiophenol, same molecule. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 2-Ethylthiophenol identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2-Ethylthiophenol is FEMA GRAS under FEMA number 3345. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 12.054, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 529, evaluated at the 53rd meeting in 1999. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 2-Ethylthiophenol appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 4500-58-7, where EPA names it Benzenethiol, 2-ethyl-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Pungent, sulfurous, earthy, musty.
Where it is used
2-Ethylthiophenol is used in savory dishes, seasoning blends, sauces and snacks, typically as a sulfur note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Ethylthiophenol by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Mercaptoanisole | 4159 | 93% | Not determined |
| Benzyl mercaptan | 2147 | 89% | In nature |
| Acetophenone | 2009 | 84% | In nature |
| 2,4-Dimethyl-5-vinylthiazole | 3145 | 80% | In nature |
| 2,6-(Dimethyl)thiophenol | 3666 | 77% | In nature |
More thiols in this index
2-Mercapto-3-butanol · Diisoamyl disulfide · 2-Methylthiophene · 4-(Methylthio)-4-methyl-2-pentanone · 2,6-(Dimethyl)thiophenol · Methyl 3-methyl-1-butenyl disulfide
2-Ethylthiophenol FAQ
Is 2-Ethylthiophenol FEMA GRAS?
Yes. The FEMA Expert Panel lists 2-Ethylthiophenol as GRAS under FEMA number 3345. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for 2-Ethylthiophenol?
2-Ethylthiophenol is FEMA 3345, CAS 4500-58-7. Its flavor category is sulfur.
How is 2-Ethylthiophenol described, and where does it show up?
Flavorists describe 2-Ethylthiophenol as pungent, sulfurous, earthy, musty. It is used in savory dishes, seasoning blends, sauces and snacks.
What did JECFA conclude about 2-Ethylthiophenol?
JECFA evaluated 2-Ethylthiophenol at the 53rd meeting in 1999 under JECFA number 529. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is 2-Ethylthiophenol on the EU Union List?
Yes. FL 12.054 is the Union List entry for 2-Ethylthiophenol, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Does 2-Ethylthiophenol count as natural in the US and the EU?
The process decides for 2-Ethylthiophenol. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic 2-Ethylthiophenol is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 2-Ethylthiophenol identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-ETHYLTHIOPHENOL under CAS 4500-58-7 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavor enhancer, flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.