Flavor ingredient regulatory record
2-Methoxy-4-methylphenol
2-Methoxy-4-methylphenol is a phenol ether in the smoky family, FEMA GRAS under FEMA number 2671 (CAS 93-51-6). Its odor is smoky, spicy, vanilla.
- FEMA
- 2671
- CAS
- 93-51-6
- JECFA
- 715
- EU FL
- 04.007
- Formula
- C8H10O2
- EC
- 202-252-9
GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 93-51-6.
Structure
Identity
Also known as: Phenol, 2-methoxy-4-methyl-, Creosol, p-Cresol, 2-methoxy-, Homoguaiacol, 4-Hydroxy-3-methoxy-1-methylbenzene, 4-Hydroxy-3-methoxytoluene, 2-Methoxy-p-cresol, p-Methylguaiacol, 4-Methylguaiacol, p-Creosol, 4-Methyl-2-methoxyphenol, 3-Methoxy-4-hydroxytoluene.
Can 2-Methoxy-4-methylphenol be labeled natural?
The process decides for 2-Methoxy-4-methylphenol. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic 2-Methoxy-4-methylphenol is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2-Methoxy-4-methylphenol is FEMA GRAS under FEMA number 2671. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 04.007, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 715, evaluated at the 55th meeting in 2000. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list. Listed on the EPA TSCA inventory.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 2-Methoxy-4-methylphenol appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 93-51-6, where EPA names it Phenol, 2-methoxy-4-methyl-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Smoky, spicy, vanilla.
Taste: Smoky, spicy.
Where it is used
2-Methoxy-4-methylphenol is used in smoke, spice and vanilla, typically as a smoky note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Methoxy-4-methylphenol by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 1-Hydroxy-2,5-dimethylbenzene | 3595 | 90% | In nature |
| Guaiacol | 2532 | 88% | In nature |
| Methoxypyrazine | 3302 | 79% | In nature |
| 2-Methoxyacetophenone | 4163 | 77% | Not determined |
| 2-Methoxybenzoic acid | 3943 | 75% | In nature |
More phenol ethers in this index
2-Methoxy-4-methylphenol FAQ
Does 2-Methoxy-4-methylphenol have FEMA GRAS status?
2-Methoxy-4-methylphenol holds FEMA GRAS status under FEMA number 2671. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite 2-Methoxy-4-methylphenol by FEMA or CAS number?
Cite 2-Methoxy-4-methylphenol as FEMA 2671 or CAS 93-51-6; both point to the same entry. Its flavor category is smoky.
What does 2-Methoxy-4-methylphenol smell and taste like, and where is it used?
The odor of 2-Methoxy-4-methylphenol is smoky, spicy, vanilla. On the palate it is smoky, spicy. Typical uses are smoke, spice and vanilla.
What did JECFA conclude about 2-Methoxy-4-methylphenol?
JECFA evaluated 2-Methoxy-4-methylphenol at the 55th meeting in 2000 under JECFA number 715. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Can 2-Methoxy-4-methylphenol be used in the EU and UK?
Yes. FL 04.007 is the Union List entry for 2-Methoxy-4-methylphenol, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Can 2-Methoxy-4-methylphenol be labeled a natural flavor?
Nature makes 2-Methoxy-4-methylphenol, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial 2-Methoxy-4-methylphenol, same molecule. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 2-Methoxy-4-methylphenol identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-METHOXY-4-METHYLPHENOL under CAS 93-51-6 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.