Flavor ingredient regulatory record
2-Tetrahydrofurfuryl 2-mercaptopropionate
2-Tetrahydrofurfuryl 2-mercaptopropionate is a thiol in the fruity family, FEMA GRAS under FEMA number 4535 (CAS 99253-91-5). Its odor is sweet, fruity, tropical, sulfurous, nutty.
- FEMA
- 4535
- CAS
- 99253-91-5
- JECFA
- 2093
- Formula
- C8H14O3S
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 99253-91-5.
Structure
Identity
Also known as: tetrahydrofuran-2-yl methyl 2-sulfanylpropanoate, (+-)-2-tetrahydrofurfuryl 2-mercaptopropionate, propanoic acid, 2-mercapto-, (tetrahydro-2-furanyl)methyl ester, 2-tetrahydrofurfuryl 2-mercaptopropionate, (+-)-, tetrahydrofurfuryl 2-mercaptopropionate, tetrahydrofuran-2-yl methyl 2-sulfanyl propanoate, (oxolan-2-yl)methyl 2-sulfanylpropanoate, oxolan-2-ylmethyl 2-sulfanylpropanoate, (+/-)-2-tetrahydrofurfuryl 2-mercaptopropionate, 2-tetrahydrofurfuryl 2-mercaptopropionate, (+/-)-.
Can 2-Tetrahydrofurfuryl 2-mercaptopropionate be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2-Tetrahydrofurfuryl 2-mercaptopropionate is FEMA GRAS under FEMA number 4535. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 2-Tetrahydrofurfuryl 2-mercaptopropionate. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2093, evaluated at the 76th meeting in 2012. no safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list. Listed on the EPA TSCA inventory.
Odor and taste
Odor: Sweet, fruity, tropical, sulfurous, nutty.
Where it is used
2-Tetrahydrofurfuryl 2-mercaptopropionate is used in beverage, confection, savory dishes and snacks, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Tetrahydrofurfuryl 2-mercaptopropionate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Diisopentyl thiomalate | 4096 | 61% | Not determined |
More thiols in this index
Methyl isobutanethioate · 3-Mercapto-2-methylpentanal · (+/-)-cis- and trans-2-Pentyl-4-propyl-1,3-oxathiane · (+/-)-2,8-Epithio-cis-p-menthane · p-Mentha-8-thiol-3-one · S-Methyl thiofuroate
2-Tetrahydrofurfuryl 2-mercaptopropionate FAQ
Is 2-Tetrahydrofurfuryl 2-mercaptopropionate on the FEMA GRAS list?
It is. FEMA number 4535 covers 2-Tetrahydrofurfuryl 2-mercaptopropionate. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for 2-Tetrahydrofurfuryl 2-mercaptopropionate?
The FEMA number for 2-Tetrahydrofurfuryl 2-mercaptopropionate is 4535 and its CAS registry number is 99253-91-5. Its flavor category is fruity.
What is 2-Tetrahydrofurfuryl 2-mercaptopropionate used for?
2-Tetrahydrofurfuryl 2-mercaptopropionate is described as sweet, fruity, tropical, sulfurous, nutty. It shows up in beverage, confection, savory dishes and snacks.
What did JECFA conclude about 2-Tetrahydrofurfuryl 2-mercaptopropionate?
JECFA evaluated 2-Tetrahydrofurfuryl 2-mercaptopropionate at the 76th meeting in 2012 under JECFA number 2093. The panel concluded: no safety concern at current levels of intake when used as a flavouring agent.
Is 2-Tetrahydrofurfuryl 2-mercaptopropionate approved in the EU?
No EU FL number is on file for 2-Tetrahydrofurfuryl 2-mercaptopropionate. It has a JECFA evaluation (JECFA 2093), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-TETRAHYDROFURFURYL 2-MERCAPTOPROPIONATE under CAS 99253-91-5 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.