Flavor ingredient regulatory record
3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one
3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one is a ketone in the fruity family, FEMA GRAS under FEMA number 4872 (CAS 35400-60-3). Its odor is sweet, fruity, floral, woody, caramel.
- FEMA
- 4872
- CAS
- 35400-60-3
- JECFA
- 2262
- EU FL
- 16.137
GRAS status: FEMA GRAS. Source: FEMA Flavor Ingredient Library.
Structure
Under review
The structure for 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: hesperetin dihydrochalcone, 3-(3-hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one, 3-(3-hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, 1-propanone, 3-(3-hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, 4-methoxy-2',4',6',3-tetrahydroxydihydrochalcone, hy-w510941, neohesperidin-dihydrochalcone ep impurity g, 3-(3-hydroxy-4-methoxy-phenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one.
Can 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one is FEMA GRAS under FEMA number 4872. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.137, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list. The entry carries use restrictions.
Use restrictions. In category 1.4 - not more than 10 mg/Kg In category 3 - not more than 10 mg/Kg In category 4.2 - not more than 10 mg/Kg In category 5.2 - not more than 10 mg/Kg In category 5.3 - not more than 10 mg/Kg In category 6.3 - not more than 10 mg/Kg In category 7.1 - not more than 10 mg/Kg In category 7.2 (only savoury crackers) - not more than 10 mg/Kg In category 12.2 - not more than 10 mg/Kg In category 12.6 - not more than 10 mg/Kg In category 14.1 - not more than 10 mg/Kg In category 14.2.1 - not more than 10 mg/Kg In category 15.1 - not more than 10 mg/Kg In category 16 (only dairy, dairy analogues, fruit and vegetable based) - Not more than 10 mg/Kg
JECFA (WHO / FAO)
JECFA number 2262.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, floral, woody, caramel.
Where it is used
3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one is used in beverage, confection, desserts and flavoring agents, typically as a fruity note.
More ketones in this index
1-Ethyl-2-acetylpyrrole · (E)-2-(2-Octenyl)cyclopentanone · 1-Penten-3-one · 2,6,6-Trimethylcyclohexanone · Methyl 2-pyrrolyl ketone · Hydroxyacetone
3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one FAQ
Is 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one FEMA GRAS?
Yes. The FEMA Expert Panel lists 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one as GRAS under FEMA number 4872. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one?
3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one is FEMA 4872, CAS 35400-60-3. FEMA files it in the fruity flavor category.
Is 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one on the EU Union List?
3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one is on the EU Union List of flavouring substances as FL 16.137 (Annex I Part A) under Regulation 1334/2008. Its entry carries use restrictions, listed on this page.
Has JECFA evaluated 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one?
Yes. JECFA number 2262.
How is 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one described, and where does it show up?
Flavorists describe 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one as sweet, fruity, floral, woody, caramel. It is used in beverage, confection, desserts and flavoring agents.
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Check 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The FEMA number and GRAS status on this page name a conclusion reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States. FDA does not list this substance by FEMA number in its Substances Added to Food inventory. Its identity is attested by EU Union List of flavouring substances, matched on CAS 35400-60-3.
FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.