Flavor ingredient regulatory record
D-Xylose
D-Xylose is an alcohol in the smoky family, FEMA GRAS under FEMA number 3606 (CAS 58-86-6). Its odor is smoky, woody, sweet, caramel.
- FEMA
- 3606
- CAS
- 58-86-6
- Formula
- C5H10O5
- EC
- 200-400-7
GRAS status: FEMA GRAS, publication 12. Recorded by FDA in the Substances Added to Food inventory under CAS 58-86-6.
Structure
Identity
Also known as: Xylose, D-, Xylose, (+)-Xylose, Wood sugar, D-(+)-Xylose, (2R,3S,4R)-2,3,4,5-Tetrahydroxypentanal, d-xylopyranose, xylopyranose, xylopyranoside, xylomed, d-xylopyranoside, d xylose.
Can D-Xylose be labeled natural?
Since D-Xylose is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when D-Xylose is synthesized. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
D-Xylose is FEMA GRAS under FEMA number 3606. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for D-Xylose. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
D-Xylose has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. D-Xylose appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 58-86-6, where EPA names it D-Xylose.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: smoky, woody, sweet, caramel.
Taste: Very sweet.
Where it is used
Typical applications for D-Xylose are not on file yet.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to D-Xylose by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| D-Sorbitol | 3029 | 83% | In nature |
| Erythritol | 4819 | 82% | In nature |
| Ascorbic Acid | 2109 | 81% | In nature |
| L-Malic Acid | 2655 | 66% | In nature |
| L-Threonine | 4710 | 66% | In nature |
D-Xylose FAQ
Is D-Xylose FEMA GRAS?
Yes. The FEMA Expert Panel lists D-Xylose as GRAS under FEMA number 3606. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for D-Xylose?
D-Xylose is FEMA 3606, CAS 58-86-6. FEMA files it in the smoky flavor category.
Does D-Xylose count as natural in the US and the EU?
D-Xylose occurs in nature, so the label depends on the route: D-Xylose won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized D-Xylose is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic D-Xylose identical-to-natural.
How is D-Xylose described, and where does it show up?
Flavorists describe D-Xylose as smoky, woody, sweet, caramel. On the palate it is very sweet.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as D-XYLOSE under CAS 58-86-6 and carries its FEMA number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant, nutritive sweetener.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.