Flavor ingredient regulatory record
Disodium Phosphate
Disodium Phosphate is a flavoring substance, FEMA GRAS under FEMA number 2398 (CAS 7558-79-4).
- FEMA
- 2398
- CAS
- 7558-79-4
- Formula
- HNa2O4P
- EC
- 231-448-7
GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 7558-79-4.
Structure
Identity
Also known as: Phosphoric acid, sodium salt (1:2), Phosphoric acid, disodium salt, Anhydrous sodium acid phosphate, Dibasic sodium phosphate, Disodium hydrogen phosphate, Disodium monohydrogen phosphate, DSP, Exsiccated sodium phosphate, Soda Phosphate, Sodium hydrogen phosphate, Sodium phosphate (Na2HPO4), Disodium orthophosphate.
Can Disodium Phosphate be labeled natural?
Since Disodium Phosphate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when Disodium Phosphate is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic Disodium Phosphate identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Disodium Phosphate is FEMA GRAS under FEMA number 2398. It is cited in the Code of Federal Regulations at 21 CFR 182.6290.
European Union and United Kingdom
No EU FL number is on file for Disodium Phosphate. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
Disodium Phosphate has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Disodium Phosphate appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 7558-79-4, where EPA names it Phosphoric acid, sodium salt (1:2).
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Taste: Saline taste.
Where it is used
Typical applications for Disodium Phosphate are not on file yet.
Disodium Phosphate FAQ
Does Disodium Phosphate have FEMA GRAS status?
Disodium Phosphate holds FEMA GRAS status under FEMA number 2398. It is also codified at 21 CFR 182.6290.
How do I cite Disodium Phosphate by FEMA or CAS number?
Cite Disodium Phosphate as FEMA 2398 or CAS 7558-79-4; both point to the same entry.
Can Disodium Phosphate be labeled a natural flavor?
Disodium Phosphate occurs in nature, so the label depends on the route: Disodium Phosphate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized Disodium Phosphate is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as SODIUM PHOSPHATE, DIBASIC under CAS 7558-79-4 and carries its FEMA number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as anticaking agent or free-flow agent, antimicrobial agent, drying agent, emulsifier or emulsifier salt, flavor enhancer, flavoring agent or adjuvant, malting or fermenting aid, ph control agent, stabilizer or thickener, texturizer.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.