Flavor ingredient regulatory record
(E,E)-2,4-Heptadienal
(E,E)-2,4-Heptadienal is an aldehyde in the fruity family, FEMA GRAS under FEMA number 3164 (CAS 4313-03-5). Its odor is green, fruity, fresh, citrus, herbaceous.
- FEMA
- 3164
- CAS
- 4313-03-5
- JECFA
- 1179
- EU FL
- 05.084
- Formula
- C7H10O
- EC
- 224-328-0
GRAS status: FEMA GRAS, publication 4. Recorded by FDA in the Substances Added to Food inventory under CAS 4313-03-5.
Structure
Identity
Also known as: 2,4-Heptadienal, (2E,4E)-, 2,4-Heptadienal, (E,E)-, (2E,4E)-2,4-Heptadienal, trans-2-trans-4-Heptadienal, trans,trans-2,4-Heptadienal, (E,E)-2,4-Heptadien-1-al, all-trans-2,4-Heptadienal, 2E,4E-Heptadienal, 2-trans-4-trans-Heptadienal, 2,4-heptadienal, (e,e)-2,4-heptadien-1-al, (2e,4z)-2,4-heptadienal.
Can (E,E)-2,4-Heptadienal be labeled natural?
(E,E)-2,4-Heptadienal occurs in nature, so the label depends on the route: (E,E)-2,4-Heptadienal won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized (E,E)-2,4-Heptadienal is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic (E,E)-2,4-Heptadienal identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
(E,E)-2,4-Heptadienal is FEMA GRAS under FEMA number 3164. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 05.084, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
Purity. At least 92 %; secondary components 2-4 % (E,Z)-2,4-heptadienal and 2-4 % 2,4-heptadienoic acid
JECFA (WHO / FAO)
JECFA number 1179, evaluated at the 61st meeting in 2003. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. (E,E)-2,4-Heptadienal appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 4313-03-5, where EPA names it 2,4-Heptadienal, (2E,4E)-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Green, fruity, fresh, citrus, herbaceous.
Taste: Slightly bitter, fresh, fruity.
Where it is used
(E,E)-2,4-Heptadienal is used in beverage, confection, fruit flavors, savory dishes and seasonings, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to (E,E)-2,4-Heptadienal by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Hept-2(trans)-enal | 3165 | 97% | In nature |
| cis-4-Heptenal | 3289 | 96% | In nature |
| 2,4-Octadienal | 3721 | 92% | In nature |
| 2,4-Heptadien-1-ol | 4127 | 91% | In nature |
| Heptanal | 2540 | 90% | In nature |
More aldehydes in this index
(E,E)-2,4-Hexadienal · Hept-2(trans)-enal · 9-Decenal · 3-(p-Isopropylphenyl)propionaldehyde · 4-Pentenal · cis-5-Octenal
(E,E)-2,4-Heptadienal FAQ
Is (E,E)-2,4-Heptadienal on the FEMA GRAS list?
It is. FEMA number 3164 covers (E,E)-2,4-Heptadienal. It is also codified at 21 CFR 172.515.
What is the FEMA number for (E,E)-2,4-Heptadienal?
The FEMA number for (E,E)-2,4-Heptadienal is 3164 and its CAS registry number is 4313-03-5. FEMA files it in the fruity flavor category.
Is (E,E)-2,4-Heptadienal natural or artificial?
Since (E,E)-2,4-Heptadienal is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when (E,E)-2,4-Heptadienal is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic (E,E)-2,4-Heptadienal identical-to-natural.
Is (E,E)-2,4-Heptadienal approved in the EU?
(E,E)-2,4-Heptadienal is on the EU Union List of flavouring substances as FL 05.084 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated (E,E)-2,4-Heptadienal?
Yes. JECFA number 1179, evaluated at the 61st meeting in 2003. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What is (E,E)-2,4-Heptadienal used for?
(E,E)-2,4-Heptadienal is described as green, fruity, fresh, citrus, herbaceous. On the palate it is slightly bitter, fresh, fruity. It shows up in beverage, confection, fruit flavors, savory dishes and seasonings.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2,4-HEPTADIENAL under CAS 4313-03-5 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.