Flavor ingredient regulatory record
Ethyl 3-(methylthio)-trans-2-propenoate
Ethyl 3-(methylthio)-trans-2-propenoate is an ester in the fruity family, FEMA GRAS under FEMA number 4564 (CAS 136115-65-6). Its odor is sweet, fruity, tropical, sulfurous, estery.
- FEMA
- 4564
- CAS
- 136115-65-6
- JECFA
- 1916
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 136115-65-6.
Structure
Under review
The structure for Ethyl 3-(methylthio)-trans-2-propenoate is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: ethyl 3-(methylthio)-(2e)-propenoate, 2-propenoic acid, 3-(methylthio)-, ethyl ester, (e)-, ethyl 3-(methylthio)-2-propenoate, (2e)-, ethyl 3-(methylthio)-2-propenoate, trans-, ethyl 3-(methylsulfanyl)prop-2-enoate, (e)-2-propenoic acid, 3-methylthio-, ethyl ester, ethyl (2e)-3-(methylsulfanyl)prop-2-enoate, ethyl 3-(methylthio)-(e)-2-propenoate, 2-propenoic acid, 3-(methylthio)-, ethyl ester, (2e)-, ethyl (e)-3-methylsulfanylprop-2-enoate, ethyl3-(methylsulfanyl)prop-2-enoate, ethyl-3-(methylthio)-(e)-2-propenoat.
Can Ethyl 3-(methylthio)-trans-2-propenoate be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Ethyl 3-(methylthio)-trans-2-propenoate is FEMA GRAS under FEMA number 4564. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Ethyl 3-(methylthio)-trans-2-propenoate. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 1916, evaluated at the 73rd meeting in 2010. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, tropical, sulfurous, estery.
Where it is used
Ethyl 3-(methylthio)-trans-2-propenoate is used in beverage, confection, fruit flavors and flavoring agents, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Ethyl 3-(methylthio)-trans-2-propenoate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Ethyl 3-(methylthio)-2-propenoate | 4565 | 100% | Not determined |
| Ethyl 3-(methylthio)-cis-2-propenoate | 4563 | 100% | Not determined |
| Butyl beta-(methylthio)acrylate | 4571 | 86% | Not determined |
| Methyl 3-(methylthio)propionate | 2720 | 74% | Not determined |
| 3-(Methylthio)propyl acetate | 3883 | 71% | In nature |
More esters in this index
Ethyl Caprylate · (E)-Ethyl 3-(2-furyl)acrylate · Bornyl butyrate · Allyl cinnamate · Anisyl phenylacetate · Butyl isovalerate
Ethyl 3-(methylthio)-trans-2-propenoate FAQ
Does ethyl 3-(methylthio)-trans-2-propenoate have FEMA GRAS status?
Ethyl 3-(methylthio)-trans-2-propenoate holds FEMA GRAS status under FEMA number 4564. It is also codified at 21 CFR 172.515.
How do I cite ethyl 3-(methylthio)-trans-2-propenoate by FEMA or CAS number?
Cite ethyl 3-(methylthio)-trans-2-propenoate as FEMA 4564 or CAS 136115-65-6; both point to the same entry. FEMA files it in the fruity flavor category.
Is ethyl 3-(methylthio)-trans-2-propenoate approved in the EU?
No EU FL number is on file for ethyl 3-(methylthio)-trans-2-propenoate. It has a JECFA evaluation (JECFA 1916), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated ethyl 3-(methylthio)-trans-2-propenoate?
Yes. JECFA number 1916, evaluated at the 73rd meeting in 2010. Conclusion: no safety concern at current levels of intake.
What does ethyl 3-(methylthio)-trans-2-propenoate smell and taste like, and where is it used?
The odor of ethyl 3-(methylthio)-trans-2-propenoate is sweet, fruity, tropical, sulfurous, estery. Typical uses are beverage, confection, fruit flavors and flavoring agents.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ETHYL 3-(METHYLTHIO)-TRANS-2-PROPENOATE under CAS 136115-65-6 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.