Flavor ingredient regulatory record
Isoeugenyl benzyl ether
Isoeugenyl benzyl ether is an ether in the floral family, FEMA GRAS under FEMA number 3698 (CAS 120-11-6). Its odor is sweet, floral, woody, aromatic.
- FEMA
- 3698
- CAS
- 120-11-6
- JECFA
- 1268
- EU FL
- 04.018
- Formula
- C17H18O2
- EC
- 204-370-6
GRAS status: FEMA GRAS, publication 13. Recorded by FDA in the Substances Added to Food inventory under CAS 120-11-6.
Structure
Identity
Also known as: Benzene, 2-methoxy-1-(phenylmethoxy)-4-(1-propen-1-yl)-, Benzene, 1-(benzyloxy)-2-methoxy-4-propenyl-, Benzene, 2-methoxy-1-(phenylmethoxy)-4-(1-propenyl)-, 2-Methoxy-1-(phenylmethoxy)-4-(1-propen-1-yl)benzene, Benzyl isoeugenol, Benzyl isoeugenol ether, Benzyl 2-methoxy-4-propenylphenyl ether, Isoeugenol, benzyl ether, NSC 46157, benzyl isoeugenol, benzene, 2-methoxy-1-(phenylmethoxy)-4-(1-propenyl)-, 1-benzyloxy-2-methoxy-4-(1-propenyl)benzene.
Can Isoeugenyl benzyl ether be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Isoeugenyl benzyl ether is FEMA GRAS under FEMA number 3698. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 04.018, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1268, evaluated at the 61st meeting in 2003. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Isoeugenyl benzyl ether appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 120-11-6, where EPA names it Benzene, 2-methoxy-1-(phenylmethoxy)-4-(1-propen-1-yl)-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, floral, woody, aromatic.
Where it is used
Isoeugenyl benzyl ether is used in beverage, confection, fragrance, flavoring and cosmetics, typically as a floral note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Isoeugenyl benzyl ether by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Eugenyl benzoate | 2471 | 86% | In nature |
| Anisyl phenylacetate | 3740 | 81% | In nature |
| Phenethyl cinnamate | 2863 | 80% | In nature |
| Benzyl cinnamate | 2142 | 80% | In nature |
| Cinnamyl cinnamate | 2298 | 79% | In nature |
More ethers in this index
Isoeugenyl methyl ether · Isoamyl phenethyl ether · Isoeugenyl ethyl ether · 1,1-Dimethoxyethane · Hydroquinone monoethyl ether · Vanillyl ethyl ether
Isoeugenyl benzyl ether FAQ
Is isoeugenyl benzyl ether on the FEMA GRAS list?
It is. FEMA number 3698 covers isoeugenyl benzyl ether. It is also codified at 21 CFR 172.515.
What is the FEMA number for isoeugenyl benzyl ether?
The FEMA number for isoeugenyl benzyl ether is 3698 and its CAS registry number is 120-11-6. FEMA files it in the floral flavor category.
Is isoeugenyl benzyl ether approved in the EU?
Isoeugenyl benzyl ether is on the EU Union List of flavouring substances as FL 04.018 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated isoeugenyl benzyl ether?
Yes. JECFA number 1268, evaluated at the 61st meeting in 2003. Conclusion: no safety concern at current levels of intake.
What is isoeugenyl benzyl ether used for?
Isoeugenyl benzyl ether is described as sweet, floral, woody, aromatic. It shows up in beverage, confection, fragrance, flavoring and cosmetics.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ISOEUGENYL BENZYL ETHER under CAS 120-11-6 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.