Flavor ingredient regulatory record
Isovaleraldehyde glyceryl acetal
Isovaleraldehyde glyceryl acetal is an aldehyde in the fruity family, FEMA GRAS under FEMA number 4380 (CAS 54355-74-7). Its odor is sweet, fruity, apple, floral, green.
- FEMA
- 4380
- CAS
- 54355-74-7
- JECFA
- 1733
- Formula
- C8H16O3
GRAS status: FEMA GRAS, publication 23. Recorded by FDA in the Substances Added to Food inventory under CAS 977188-22-9.
Structure
Identity
Also known as: (2-isobutyl-1,3-dioxolan-4-yl)methanol, 4-hydroxymethyl-2-(2-methylpropyl)-1,3-dioxolane, 1,3-dioxolane-4-methanol, 2-(2-methylpropyl)-, (+-)-4-hydroxymethyl-2-(2-methylpropyl)-1,3-dioxolane, 3-methylbutyraldehyde 1,2-glyceryl acetal, [2-(2-methylpropyl)-1,3-dioxolan-4-yl]methanol.
Can Isovaleraldehyde glyceryl acetal be labeled natural?
Isovaleraldehyde glyceryl acetal occurs in nature, so the label depends on the route: isovaleraldehyde glyceryl acetal won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized isovaleraldehyde glyceryl acetal is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Isovaleraldehyde glyceryl acetal is FEMA GRAS under FEMA number 4380. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Isovaleraldehyde glyceryl acetal. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 1733, evaluated at the 68th meeting in 2007. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, apple, floral, green.
Where it is used
Isovaleraldehyde glyceryl acetal is used in beverage, confection, flavoring, baked goods and snacks, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Isovaleraldehyde glyceryl acetal by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Heptanal glyceryl acetal | 2542 | 74% | Not determined |
More aldehydes in this index
2,3-Epoxyheptanal · trans-2-Hexenal propylene glycol acetal · (2E, 4E)-undeca-2,4-dienal · Undecanal · 1,3-p-Menthadien-7-al · (+/-)-4-Ethyloctanal
Isovaleraldehyde glyceryl acetal FAQ
Is isovaleraldehyde glyceryl acetal FEMA GRAS?
Yes. The FEMA Expert Panel lists isovaleraldehyde glyceryl acetal as GRAS under FEMA number 4380. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for isovaleraldehyde glyceryl acetal?
Isovaleraldehyde glyceryl acetal is FEMA 4380, CAS 54355-74-7. FEMA files it in the fruity flavor category.
Does isovaleraldehyde glyceryl acetal count as natural in the US and the EU?
Since isovaleraldehyde glyceryl acetal is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when isovaleraldehyde glyceryl acetal is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Is isovaleraldehyde glyceryl acetal approved in the EU?
No EU FL number is on file for isovaleraldehyde glyceryl acetal. It has a JECFA evaluation (JECFA 1733), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated isovaleraldehyde glyceryl acetal?
Yes. JECFA number 1733, evaluated at the 68th meeting in 2007. Conclusion: no safety concern at current levels of intake.
How is isovaleraldehyde glyceryl acetal described, and where does it show up?
Flavorists describe isovaleraldehyde glyceryl acetal as sweet, fruity, apple, floral, green. It is used in beverage, confection, flavoring, baked goods and snacks.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ISOVALERALDEHYDE GLYCERYL ACETAL under CAS 977188-22-9 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.