Flavor ingredient regulatory record

Nerol

Nerol is a terpene alcohol in the floral family, FEMA GRAS under FEMA number 2770 (CAS 106-25-2). Its odor is rose, fresh, citrus, sweet, neroli.

FEMA
2770
CAS
106-25-2
JECFA
1224
EU FL
02.058
Formula
C10H18O
EC
203-378-7

GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 106-25-2.

Structure

2D structure of Nerol
Structure of Nerol, C10H18O. Drawn from the canonical SMILES.

Identity

IUPAC name (2Z)-3,7-dimethylocta-2,6-dien-1-ol
CAS number 106-25-2
FEMA number 2770
Molecular formula C10H18O
Molecular weight 154.25 g/mol
SMILES CC(C)=CCC/C(C)=C\CO
InChIKey GLZPCOQZEFWAFX-YFHOEESVSA-N
PubChem CID 643820
EC number 203-378-7
FDA UNII 38G5P53250
EPA DTXSID DTXSID3026728
Chemical class Terpene alcohol
Boiling point 220 °C
Flash point 108 °C

Also known as: 2,6-Octadien-1-ol, 3,7-dimethyl-, (2Z)-, 2,6-Octadien-1-ol, 3,7-dimethyl-, (Z)-, (2Z)-3,7-Dimethyl-2,6-octadien-1-ol, cis-3,7-Dimethyl-2,6-octadien-1-ol, cis-Geraniol, Neryl alcohol, β-Nerol, (Z)-Geraniol, (Z)-3,7-Dimethyl-2,6-octadien-1-ol, 3,7-Dimethyl-cis-2,6-octadien-1-ol, (Z)-Nerol, 2-cis-3,7-Dimethyl-2,6-octadien-1-ol.

Can Nerol be labeled natural?

Since nerol is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when nerol is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic nerol identical-to-natural.

United States
Natural or artificial, by process
European Union and UK
Natural only from natural material
Mercosur and Mexico
Natural or identical-to-natural

How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.

Regulatory status, with citations

United States

Nerol is FEMA GRAS under FEMA number 2770. It is cited in the Code of Federal Regulations at 21 CFR 172.515.

21 CFR 172.515

European Union and United Kingdom

Listed on the Union List of flavouring substances as FL 02.058, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.

JECFA (WHO / FAO)

JECFA number 1224, evaluated at the 61st meeting in 2003. No safety concern at current levels of intake when used as a flavouring agent.

JECFA monograph

Other US flags

Not on the California Proposition 65 list.

TSCA Inventory status

A flavor ingredient is also an industrial chemical. Nerol appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 106-25-2, where EPA names it 2,6-Octadien-1-ol, 3,7-dimethyl-, (2Z)-.

Active in US commerce

EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.

EPA publishes no regulatory flags on this listing. What the flags mean.

From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.

Odor and taste

Odor: Rose, fresh, citrus, sweet, neroli.

Taste: Floral, citrus, rose-like.

Where it is used

Nerol is used in rose, neroli, citrus and floral, typically as a floral note.

Structurally similar flavor ingredients

Flavor ingredients with a GRAS determination closest to Nerol by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.

MaterialFEMASimilarityOccurrence
Geraniol2507100%In nature
(-)-3,7-Dimethyl-6-octen-1-ol230995%In nature
Citral230390%In nature
Citronellal230781%In nature
(E,Z)-Geranic acid412180%In nature

More terpene alcohols in this index

Geraniol · Linalool · alpha-Terpineol · 4-(p-Hydroxyphenyl)-2-butanone · l-Menthol

Nerol FAQ

Does nerol have FEMA GRAS status?

Nerol holds FEMA GRAS status under FEMA number 2770. It is also codified at 21 CFR 172.515.

How do I cite nerol by FEMA or CAS number?

Cite nerol as FEMA 2770 or CAS 106-25-2; both point to the same entry. FEMA files it in the floral flavor category.

Can nerol be labeled a natural flavor?

Nerol occurs in nature, so the label depends on the route: nerol won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized nerol is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.

Can nerol be used in the EU and UK?

Nerol is on the EU Union List of flavouring substances as FL 02.058 (Annex I Part A) under Regulation 1334/2008.

Has JECFA evaluated nerol?

Yes. JECFA number 1224, evaluated at the 61st meeting in 2003. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.

What does nerol smell and taste like, and where is it used?

The odor of nerol is rose, fresh, citrus, sweet, neroli. On the palate it is floral, citrus, rose-like. Typical uses are rose, neroli, citrus and floral.

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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification

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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as NEROL under CAS 106-25-2 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.

A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.

Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.

About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.