Flavor ingredient regulatory record
(S)-1-Methoxy-3-heptanthiol
(S)-1-Methoxy-3-heptanthiol is a thiol in the fruity family, FEMA GRAS under FEMA number 4162 (CAS 400052-49-5). Its odor is sweet, fruity, tropical, sulfurous, herbal.
- FEMA
- 4162
- CAS
- 400052-49-5
- JECFA
- 1671
- EU FL
- 12.276
- Formula
- C8H18OS
GRAS status: FEMA GRAS, publication 22. Recorded by FDA in the Substances Added to Food inventory under CAS 400052-49-5.
Structure
Identity
Also known as: 3-Heptanethiol, 1-methoxy-, (3S)-, (3S)-1-Methoxy-3-heptanethiol, (s)-1-methoxy-3-heptanethiol, 1-methoxy-3-heptanethiol, (3s)-, 3-heptanethiol, 1-methoxy-, (3s)-, (3s)-1-methoxyheptane-3-thiol, (s1)-1-methoxy-3-heptanethiol [fhfi], (3s)-1-methoxy-3-heptanethiol, (s1)-1-methoxy-3-heptanethiol, (s1)-methoxy-3-heptanethiol, 2-heptoxyethanethiol.
Can (S)-1-Methoxy-3-heptanthiol be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
(S)-1-Methoxy-3-heptanthiol is FEMA GRAS under FEMA number 4162. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 12.276, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1671, evaluated at the 68th meeting in 2007. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list. Listed on the EPA TSCA inventory.
Odor and taste
Odor: Sweet, fruity, tropical, sulfurous, herbal.
Taste: Sweet, fruity, savory.
Where it is used
(S)-1-Methoxy-3-heptanthiol is used in beverage, confection, fruit flavors, savory dishes and snacks, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to (S)-1-Methoxy-3-heptanthiol by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| cis-3-Octen-1-ol | 3467 | 70% | In nature |
| cis-5-Octenal | 3749 | 65% | In nature |
| 3-Mercaptohexanol | 3850 | 64% | In nature |
| cis-6-Nonenal | 3580 | 61% | In nature |
More thiols in this index
1-(3-(Methylthio)-butyryl)-2,6,6-trimethylcyclohexene · S-Furfuryl thiopropionate · 2-Pentenyl-4-propyl-1,3-oxathiane · 2-Methyl-4-propyl-1,3-oxathiane · Triethylthialdine · S-Methyl 3-methylbutanethioate
(S)-1-Methoxy-3-heptanthiol FAQ
Does (S)-1-Methoxy-3-heptanthiol have FEMA GRAS status?
(S)-1-Methoxy-3-heptanthiol holds FEMA GRAS status under FEMA number 4162. It is also codified at 21 CFR 172.515.
How do I cite (S)-1-Methoxy-3-heptanthiol by FEMA or CAS number?
Cite (S)-1-Methoxy-3-heptanthiol as FEMA 4162 or CAS 400052-49-5; both point to the same entry. FEMA files it in the fruity flavor category.
Can (S)-1-Methoxy-3-heptanthiol be used in the EU and UK?
(S)-1-Methoxy-3-heptanthiol is on the EU Union List of flavouring substances as FL 12.276 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated (S)-1-Methoxy-3-heptanthiol?
Yes. JECFA number 1671, evaluated at the 68th meeting in 2007. Conclusion: no safety concern at current levels of intake.
What does (S)-1-Methoxy-3-heptanthiol smell and taste like, and where is it used?
The odor of (S)-1-Methoxy-3-heptanthiol is sweet, fruity, tropical, sulfurous, herbal. On the palate it is sweet, fruity, savory. Typical uses are beverage, confection, fruit flavors, savory dishes and snacks.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as (S1)-METHOXY-3-HEPTANETHIOL under CAS 400052-49-5 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.