Will Pemble

Articles

• FL Number Prefixes and the EU Chemical Groups

  September 14, 2026

  EU flavoring law has two chemical group schemes: the 34 groups in Regulation 1565/2000 and the 17 FL number prefixes in the Union list. They do not line up.

• The PMN Flag Means the Notice Already Happened

  September 14, 2026

  A TSCA PMN flag marks a commenced premanufacture notice substance, an existing chemical you do not file a PMN for. About 52% have no public CAS number.

• The S Flag: Significant New Use Rules on the TSCA Inventory

  September 14, 2026

  A TSCA S flag means a significant new use rule applies. A listed, active substance can still need a notice to EPA 90 days before the new use begins.

• What the XU Flag Means on the TSCA Inventory

  September 14, 2026

  XU marks a substance fully exempt from TSCA Chemical Data Reporting. The exemption belongs to the substance rather than to you, and it can lapse.

• Active vs Inactive on the TSCA Inventory

  September 14, 2026

  About half the TSCA Inventory is inactive. Making one again takes a Notice of Activity Form B first, and the rule's 90 days is not a waiting period.

• FLAVIS and FL Numbers: the EU Union List

  September 13, 2026

  An FL number identifies a flavoring substance in the EU. What the Union list holds, the two defaults hiding in its columns, and why the 2012 text misleads.

• 21 CFR 172.510: Natural Flavoring Botanicals

  September 13, 2026

  21 CFR 172.510 permits 130 botanicals as natural flavorings and attaches a condition to 31. What the conditions mean, and why wormwood covers a whole genus.

• 21 CFR 172.515: Synthetic Flavoring Substances

  September 12, 2026

  21 CFR 172.515 lists more than 700 synthetic flavoring substances FDA allows in food. How it differs from 182.60, and the six FDA removed in 2018.

• How to File a GRAS Notification with the FDA

  July 18, 2026

  How to file a GRAS notice with the FDA: the seven parts under 21 CFR 170.225 to 170.255, how to submit, the 180-day review, and the GRAS Notice Inventory.

• 21 CFR 101.22: Natural vs Artificial Flavor

  July 18, 2026

  The full 21 CFR 101.22(a)(3) natural flavor definition, the (i) rules for when a label must say flavored or artificially flavored, and what (j) requires.

• What Is FEMA GRAS? Flavor Ingredient Safety

  July 18, 2026

  FEMA GRAS means the FEMA Expert Panel has concluded a flavor ingredient is Generally Recognized As Safe for its intended use. Search any FEMA number for free.

• What Is an AI Flavor Formulator?

  July 18, 2026

  An AI flavor formulator turns a brief into a first-draft formula for a flavorist to refine. How it differs from a chatbot, and how to tell a good one.

• How much does regulatory and labeling work actually cost you?

  July 14, 2026

  What your current stack costs in dollars and chemist-weeks, with an interactive calculator so you can see it for your own portfolio.