Flavor ingredient regulatory record
2,4,5-Trimethylthiazole
2,4,5-Trimethylthiazole is a thiazole in the savory family, FEMA GRAS under FEMA number 3325 (CAS 13623-11-5). Its odor is nutty, roasted, earthy, meaty.
- FEMA
- 3325
- CAS
- 13623-11-5
- JECFA
- 1036
- EU FL
- 15.019
- Formula
- C6H9NS
- EC
- 237-107-9
GRAS status: FEMA GRAS, publication 5. Recorded by FDA in the Substances Added to Food inventory under CAS 13623-11-5.
Structure
Identity
Also known as: Thiazole, 2,4,5-trimethyl-, Thiazole, trimethyl-, Trimethylthiazole, NSC 170614, 2,4,5-Trimethyl-1,3-thiazole, trimethylthiazole, trimethyl-1,3-thiazole, thiazole, 2,4,5-trimethyl-, trimethyl thiazole, 2,4,5-trimethyl-1,3-thiazole, thiazole, trimethyl-, 2,4,5-trimethyl thiazole.
Can 2,4,5-Trimethylthiazole be labeled natural?
Nature makes 2,4,5-Trimethylthiazole, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial 2,4,5-Trimethylthiazole, same molecule. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2,4,5-Trimethylthiazole is FEMA GRAS under FEMA number 3325. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 15.019, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1036, evaluated at the 64th meeting in 2005. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 2,4,5-Trimethylthiazole appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 13623-11-5, where EPA names it Thiazole, 2,4,5-trimethyl-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Nutty, roasted, earthy, meaty.
Where it is used
2,4,5-Trimethylthiazole is used in savory snacks, seasonings, meat products and broths, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2,4,5-Trimethylthiazole by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Trimethyloxazole | 4394 | 86% | In nature |
| 2,4-Dimethyl-5-vinylthiazole | 3145 | 81% | In nature |
| 5-Ethyl-2-methylthiazole | 4388 | 80% | In nature |
| 2,4-Dimethyl-5-acetylthiazole | 3267 | 76% | In nature |
| 4-Methyl-5-vinylthiazole | 3313 | 75% | In nature |
More thiazoles in this index
2,4-Dimethyl-5-acetylthiazole · 4-Methyl-5-vinylthiazole · 2-Ethyl-2,5-dihydro-4-methylthiazole · 2-Isobutylthiazole · 2-Propionylthiazole · 2-Methyl-5-methoxythiazole
2,4,5-Trimethylthiazole FAQ
Does 2,4,5-Trimethylthiazole have FEMA GRAS status?
2,4,5-Trimethylthiazole holds FEMA GRAS status under FEMA number 3325. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite 2,4,5-Trimethylthiazole by FEMA or CAS number?
Cite 2,4,5-Trimethylthiazole as FEMA 3325 or CAS 13623-11-5; both point to the same entry. Its flavor category is savory.
What does 2,4,5-Trimethylthiazole smell and taste like, and where is it used?
The odor of 2,4,5-Trimethylthiazole is nutty, roasted, earthy, meaty. Typical uses are savory snacks, seasonings, meat products and broths.
What did JECFA conclude about 2,4,5-Trimethylthiazole?
JECFA evaluated 2,4,5-Trimethylthiazole at the 64th meeting in 2005 under JECFA number 1036. The panel concluded: no safety concern at current levels of intake.
Can 2,4,5-Trimethylthiazole be used in the EU and UK?
Yes. FL 15.019 is the Union List entry for 2,4,5-Trimethylthiazole, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Can 2,4,5-Trimethylthiazole be labeled a natural flavor?
The process decides for 2,4,5-Trimethylthiazole. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic 2,4,5-Trimethylthiazole is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2,4,5-TRIMETHYLTHIAZOLE under CAS 13623-11-5 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.