Flavor ingredient regulatory record
2,5-Dimethyl-3-thiofuroylfuran
2,5-Dimethyl-3-thiofuroylfuran is a thiofuran in the fruity family, FEMA GRAS under FEMA number 3481 (CAS 65505-16-0). Its odor is sweet, fruity, sulfurous, nutty, earthy.
- FEMA
- 3481
- CAS
- 65505-16-0
- JECFA
- 1071
- EU FL
- 13.040
- Formula
- C11H10O3S
- EC
- 265-796-6
GRAS status: FEMA GRAS, publication 10. Recorded by FDA in the Substances Added to Food inventory under CAS 55764-31-3.
Structure
Identity
Also known as: 3-Furancarbothioic acid, S-(2,5-dimethyl-3-furanyl) ester, S-(2,5-Dimethyl-3-furanyl) 3-furancarbothioate, s-(2,5-dimethylfuran-3-yl) furan-3-carbothioate, 3-furancarbothioicacid, s-(2,5-dimethyl-3-furanyl) ester, s-(2,5-dimethyl-3-furyl) thio-3-furoate, 3-furancarbothioic acid, s-(2,5-dimethyl-3-furanyl) ester, [(2,5-dimethylfuran-3-yl)sulfanyl](furan-3-yl)methanone, s-(2,5-dimethyl-3-furyl) furan-3-carbothioate, as-70069, 2,5-dimethyl-3-thiofuroylfuran [fhfi], furoylthio)-2,5-dimethylfuran, 3-(2-.
Can 2,5-Dimethyl-3-thiofuroylfuran be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2,5-Dimethyl-3-thiofuroylfuran is FEMA GRAS under FEMA number 3481. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 13.040, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1071, evaluated at the 59th meeting in 2002. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, sulfurous, nutty, earthy.
Where it is used
2,5-Dimethyl-3-thiofuroylfuran is used in beverage, confection, savory snacks, seasoning and flavoring agents, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2,5-Dimethyl-3-thiofuroylfuran by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Methyl-3,5 and 6-(furfurylthio)pyrazine | 3189 | 76% | Not determined |
| bis-(2-Methyl-3-furyl) disulfide | 3259 | 74% | In nature |
| 2,4-Difurfurylfuran | 4095 | 69% | Not determined |
| 3-[(2-Methyl-3-furyl)thio]-4-heptanone | 3570 | 69% | In nature |
| O-Ethyl-S-(2-furylmethyl) thiocarbonate | 4043 | 69% | In nature |
2,5-Dimethyl-3-thiofuroylfuran FAQ
Does 2,5-Dimethyl-3-thiofuroylfuran have FEMA GRAS status?
2,5-Dimethyl-3-thiofuroylfuran holds FEMA GRAS status under FEMA number 3481. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite 2,5-Dimethyl-3-thiofuroylfuran by FEMA or CAS number?
Cite 2,5-Dimethyl-3-thiofuroylfuran as FEMA 3481 or CAS 65505-16-0; both point to the same entry. Its flavor category is fruity.
What does 2,5-Dimethyl-3-thiofuroylfuran smell and taste like, and where is it used?
The odor of 2,5-Dimethyl-3-thiofuroylfuran is sweet, fruity, sulfurous, nutty, earthy. Typical uses are beverage, confection, savory snacks, seasoning and flavoring agents.
What did JECFA conclude about 2,5-Dimethyl-3-thiofuroylfuran?
JECFA evaluated 2,5-Dimethyl-3-thiofuroylfuran at the 59th meeting in 2002 under JECFA number 1071. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Can 2,5-Dimethyl-3-thiofuroylfuran be used in the EU and UK?
Yes. FL 13.040 is the Union List entry for 2,5-Dimethyl-3-thiofuroylfuran, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 3-(2-FUROYLTHIO)-2,5-DIMETHYLFURAN under CAS 55764-31-3 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavor enhancer, flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.