Flavor ingredient regulatory record
2-Methyl-3,5 and 6-(furfurylthio)pyrazine
2-Methyl-3,5 and 6-(furfurylthio)pyrazine is a pyrazine in the savory family, FEMA GRAS under FEMA number 3189 (CAS 65530-53-2). Its odor is nutty, roasted, earthy, savory, complex.
- FEMA
- 3189
- CAS
- 65530-53-2
- JECFA
- 1082
- EU FL
- 13.151
GRAS status: FEMA GRAS, publication 4. Recorded by FDA in the Substances Added to Food inventory under CAS 59035-98-2.
Structure
Under review
The structure for 2-Methyl-3,5 and 6-(furfurylthio)pyrazine is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: Pyrazine, 2-[(3-furanylmethyl)thio]methyl-, Pyrazine, [(3-furanylmethyl)thio]methyl-, 2-[(3-Furanylmethyl)thio]methylpyrazine, 2-furfurylthio-3-methylpyrazine, 2-methyl-3-(furfurylthio)pyrazine, pyrazine, 2-[(2-furanylmethyl)thio]-3-methyl-, 2-(2-furylmethylsulfanyl)-3-methyl-pyrazine, pyrazine, 2-((2-furanylmethyl)thio)-3-methyl-, 2-[(furan-2-ylmethyl)sulfanyl]-3-methylpyrazine, furfuryl 2-methyl-3-pyrazinyl sulfide, 2-((furan-2-ylmethyl)sulfanyl)-3-methylpyrazine, pyrazine, 2-(2-furanylmethyl)thio-3-methyl-.
Can 2-Methyl-3,5 and 6-(furfurylthio)pyrazine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2-Methyl-3,5 and 6-(furfurylthio)pyrazine is FEMA GRAS under FEMA number 3189. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 13.151, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
Purity. Mixture of isomers: 70% 2,3-; 29% 2,6;-trace 2,5-
JECFA (WHO / FAO)
JECFA number 1082, evaluated at the 59th meeting in 2002. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Nutty, roasted, earthy, savory, complex.
Where it is used
2-Methyl-3,5 and 6-(furfurylthio)pyrazine is used in snack foods, seasonings, sauces and meat products, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Methyl-3,5 and 6-(furfurylthio)pyrazine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2,5-Dimethyl-3-thiofuroylfuran | 3481 | 73% | Not determined |
| S-Furfuryl thiopropionate | 3347 | 72% | In nature |
| O-Ethyl-S-(2-furylmethyl) thiocarbonate | 4043 | 69% | In nature |
More pyrazines in this index
2-Methyl-5-vinylpyrazine · 5-Methylquinoxaline · 2-Ethyl-3-methylthiopyrazine · 2-Acetyl-3-methylpyrazine · 2-Isobutyl-3-methoxypyrazine · 2,3,5,6-Tetramethylpyrazine
2-Methyl-3,5 and 6-(furfurylthio)pyrazine FAQ
Is 2-Methyl-3,5 and 6-(furfurylthio)pyrazine FEMA GRAS?
Yes. The FEMA Expert Panel lists 2-Methyl-3,5 and 6-(furfurylthio)pyrazine as GRAS under FEMA number 3189. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for 2-Methyl-3,5 and 6-(furfurylthio)pyrazine?
2-Methyl-3,5 and 6-(furfurylthio)pyrazine is FEMA 3189, CAS 65530-53-2. Its flavor category is savory.
How is 2-Methyl-3,5 and 6-(furfurylthio)pyrazine described, and where does it show up?
Flavorists describe 2-Methyl-3,5 and 6-(furfurylthio)pyrazine as nutty, roasted, earthy, savory, complex. It is used in snack foods, seasonings, sauces and meat products.
What did JECFA conclude about 2-Methyl-3,5 and 6-(furfurylthio)pyrazine?
JECFA evaluated 2-Methyl-3,5 and 6-(furfurylthio)pyrazine at the 59th meeting in 2002 under JECFA number 1082. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is 2-Methyl-3,5 and 6-(furfurylthio)pyrazine on the EU Union List?
Yes. FL 13.151 is the Union List entry for 2-Methyl-3,5 and 6-(furfurylthio)pyrazine, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-METHYL-3 OR 5 OR 6-(FURFURYLTHIO)PYRAZINE (MIXTURE OF ISOMERS) under CAS 59035-98-2 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.