Flavor ingredient regulatory record
5-Methylquinoxaline
5-Methylquinoxaline is a pyrazine in the savory family, FEMA GRAS under FEMA number 3203 (CAS 13708-12-8). Its odor is nutty, roasted, earthy, meaty.
- FEMA
- 3203
- CAS
- 13708-12-8
- JECFA
- 798
- EU FL
- 14.028
- Formula
- C9H8N2
- EC
- 237-246-5
GRAS status: FEMA GRAS, publication 4. Recorded by FDA in the Substances Added to Food inventory under CAS 13708-12-8.
Structure
Identity
Also known as: Quinoxaline, 5-methyl-, quinoxaline, 5-methyl-, 5-methyl quinoxaline, 8-methylquinoxaline, 5-methyl-1,4-naphthyridine, 8-methyl-1,4-naphthyridine, 5-methylquinoxaline [fhfi], 5-methyl-quinoxaline, 5-methyl-quinoxalin, 5-(methyl)-quinoxaline, epitope id:547124, 5-methylquinoxaline, 98%.
Can 5-Methylquinoxaline be labeled natural?
The process decides for 5-Methylquinoxaline. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic 5-Methylquinoxaline is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 5-Methylquinoxaline identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
5-Methylquinoxaline is FEMA GRAS under FEMA number 3203. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 14.028, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 798, evaluated at the 57th meeting in 2001. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 5-Methylquinoxaline appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 13708-12-8, where EPA names it Quinoxaline, 5-methyl-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Nutty, roasted, earthy, meaty.
Where it is used
5-Methylquinoxaline is used in savory snacks, seasonings, meat products and sauces, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 5-Methylquinoxaline by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Isoquinoline | 2978 | 88% | In nature |
| 6-Methylquinoline | 2744 | 83% | In nature |
| 1-Methylnaphthalene | 3193 | 83% | In nature |
| 6-Methoxyquinoline | 4640 | 82% | Not determined |
| 2-Methyl-4,5-benzo-oxazole | 4398 | 73% | In nature |
More pyrazines in this index
2-Methyl-5-vinylpyrazine · 2-Ethyl-3-methylthiopyrazine · 2-Methyl-3,5 and 6-(furfurylthio)pyrazine · trans-Nonenal · 2,5-Dimethylpyrazine · 2-Ethoxy-3-methylpyrazine
5-Methylquinoxaline FAQ
Is 5-Methylquinoxaline on the FEMA GRAS list?
It is. FEMA number 3203 covers 5-Methylquinoxaline. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for 5-Methylquinoxaline?
The FEMA number for 5-Methylquinoxaline is 3203 and its CAS registry number is 13708-12-8. Its flavor category is savory.
What is 5-Methylquinoxaline used for?
5-Methylquinoxaline is described as nutty, roasted, earthy, meaty. It shows up in savory snacks, seasonings, meat products and sauces.
What did JECFA conclude about 5-Methylquinoxaline?
JECFA evaluated 5-Methylquinoxaline at the 57th meeting in 2001 under JECFA number 798. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is 5-Methylquinoxaline approved in the EU?
Yes. FL 14.028 is the Union List entry for 5-Methylquinoxaline, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Is 5-Methylquinoxaline natural or artificial?
Nature makes 5-Methylquinoxaline, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial 5-Methylquinoxaline, same molecule. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 5-METHYLQUINOXALINE under CAS 13708-12-8 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.