Flavor ingredient regulatory record
2-Ethyl-3-methylthiopyrazine
2-Ethyl-3-methylthiopyrazine is a pyrazine in the savory family, FEMA GRAS under FEMA number 4631 (CAS 72987-62-3). Its odor is earthy, nutty, roasted, savory.
- FEMA
- 4631
- CAS
- 72987-62-3
- JECFA
- 2132
- Formula
- C7H10N2S
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 72987-62-3.
Structure
Identity
Also known as: Pyrazine, 2-ethyl-3-(methylthio)-, 2-Ethyl-3-(methylthio)pyrazine, 2-(Methylthio)-3-ethylpyrazine, 2-Ethyl-3-(methylsulfanyl)pyrazine, 2-ethyl-3-(methylthio)pyrazine, 2-(methylthio)-3-ethylpyrazine, pyrazine, 2-ethyl-3-(methylthio)-, 3-ethyl-2-(methylthio)pyrazine, pyrazine, 3-ethyl-2-(methylthio), 3-ethyl-2-methylthiopyrazine, 2-ethyl-3-(methylsulfanyl)pyrazine, 2-ethyl-3-methylsulfanylpyrazine.
Can 2-Ethyl-3-methylthiopyrazine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2-Ethyl-3-methylthiopyrazine is FEMA GRAS under FEMA number 4631. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 2-Ethyl-3-methylthiopyrazine. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2132, evaluated at the 76th meeting in 2012. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 2-Ethyl-3-methylthiopyrazine appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 72987-62-3, where EPA names it Pyrazine, 2-ethyl-3-(methylthio)-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Earthy, nutty, roasted, savory.
Where it is used
2-Ethyl-3-methylthiopyrazine is used in savory snacks, seasonings, soups and meat products, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Ethyl-3-methylthiopyrazine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Ethylpyrazine | 3281 | 78% | In nature |
| 2-Acetyl-3-ethylpyrazine | 3250 | 73% | In nature |
| 2-Ethoxy-3-methylpyrazine | 3569 | 73% | In nature |
| 2,3-Diethyl-5-methylpyrazine | 3336 | 72% | In nature |
More pyrazines in this index
5-Methylquinoxaline · 2-Methyl-3,5 and 6-(furfurylthio)pyrazine · 2-Methyl-5-vinylpyrazine · 2,3-Diethyl-5-methylpyrazine · 2-Acetyl-1-pyrroline · Methoxypyrazine
2-Ethyl-3-methylthiopyrazine FAQ
Is 2-Ethyl-3-methylthiopyrazine on the FEMA GRAS list?
It is. FEMA number 4631 covers 2-Ethyl-3-methylthiopyrazine. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for 2-Ethyl-3-methylthiopyrazine?
The FEMA number for 2-Ethyl-3-methylthiopyrazine is 4631 and its CAS registry number is 72987-62-3. Its flavor category is savory.
What is 2-Ethyl-3-methylthiopyrazine used for?
2-Ethyl-3-methylthiopyrazine is described as earthy, nutty, roasted, savory. It shows up in savory snacks, seasonings, soups and meat products.
What did JECFA conclude about 2-Ethyl-3-methylthiopyrazine?
JECFA evaluated 2-Ethyl-3-methylthiopyrazine at the 76th meeting in 2012 under JECFA number 2132. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is 2-Ethyl-3-methylthiopyrazine approved in the EU?
No EU FL number is on file for 2-Ethyl-3-methylthiopyrazine. It has a JECFA evaluation (JECFA 2132), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-ETHYL-3-METHYLTHIOPYRAZINE under CAS 72987-62-3 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.