Flavor ingredient regulatory record
2-Methyl-3-thioacetoxy-4,5-dihydrofuran
2-Methyl-3-thioacetoxy-4,5-dihydrofuran is a thioester in the fruity family, FEMA GRAS under FEMA number 3636 (CAS 26486-14-6). Its odor is sweet, fruity, tropical, sulfurous, herbal.
- FEMA
- 3636
- CAS
- 26486-14-6
- JECFA
- 1089
- EU FL
- 13.086
- Formula
- C7H10O2S
- EC
- 247-731-3
GRAS status: FEMA GRAS, publication 12. Recorded by FDA in the Substances Added to Food inventory under CAS 26486-14-6.
Structure
Identity
Also known as: Ethanethioic acid, S-(4,5-dihydro-2-methyl-3-furanyl) ester, Acetic acid, thio-, S-(4,5-dihydro-2-methyl-3-furyl) ester, 3-Furanthiol, 4,5-dihydro-2-methyl-, acetate, S-(4,5-Dihydro-2-methyl-3-furanyl) ethanethioate, 1-[(2-Methyl-4,5-dihydrofuran-3-yl)sulfanyl]ethan-1-one, s-(4,5-dihydro-2-methyl-3-furanyl) ethanethioate, 4,5-dihydro-2-methyl-3-furanthiyl acetate, s-(4,5-dihydro-2-methyl-3-furyl) thioacetate, 2-methyl-4,5-dihydro-3-furanthiol acetate, 3-furanthiol, 4,5-dihydro-2-methyl-, acetate, acetic acid, thio-, s-(4,5-dihydro-2-methyl-3-furyl) ester, 1-[(2-methyl-4,5-dihydrofuran-3-yl)sulfanyl]ethan-1-one.
Can 2-Methyl-3-thioacetoxy-4,5-dihydrofuran be labeled natural?
2-Methyl-3-thioacetoxy-4,5-dihydrofuran occurs in nature, so the label depends on the route: 2-Methyl-3-thioacetoxy-4,5-dihydrofuran won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized 2-Methyl-3-thioacetoxy-4,5-dihydrofuran is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2-Methyl-3-thioacetoxy-4,5-dihydrofuran is FEMA GRAS under FEMA number 3636. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 13.086, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1089, evaluated at the 59th meeting in 2002. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, tropical, sulfurous, herbal.
Where it is used
2-Methyl-3-thioacetoxy-4,5-dihydrofuran is used in beverage, confection, fruit flavors and savory dishes, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Methyl-3-thioacetoxy-4,5-dihydrofuran by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Ethanethoic acid, S-(2-methyl-3-furanyl) ester | 3973 | 92% | Not determined |
| 2-Acetyl-5-methylthiophene | 4643 | 78% | In nature |
| 2-Acetyl-5-methylfuran | 3609 | 77% | In nature |
| 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers | 3972 | 71% | Not determined |
| Propyl thioacetate | 3385 | 63% | In nature |
More thioesters in this index
Propyl thioacetate · 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers · S-Methyl 2-methylbutanethioate · Menthone-8-thioacetate · S-Furfuryl thioacetate
2-Methyl-3-thioacetoxy-4,5-dihydrofuran FAQ
Is 2-Methyl-3-thioacetoxy-4,5-dihydrofuran FEMA GRAS?
Yes. The FEMA Expert Panel lists 2-Methyl-3-thioacetoxy-4,5-dihydrofuran as GRAS under FEMA number 3636. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for 2-Methyl-3-thioacetoxy-4,5-dihydrofuran?
2-Methyl-3-thioacetoxy-4,5-dihydrofuran is FEMA 3636, CAS 26486-14-6. FEMA files it in the fruity flavor category.
Does 2-Methyl-3-thioacetoxy-4,5-dihydrofuran count as natural in the US and the EU?
Since 2-Methyl-3-thioacetoxy-4,5-dihydrofuran is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when 2-Methyl-3-thioacetoxy-4,5-dihydrofuran is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Is 2-Methyl-3-thioacetoxy-4,5-dihydrofuran on the EU Union List?
2-Methyl-3-thioacetoxy-4,5-dihydrofuran is on the EU Union List of flavouring substances as FL 13.086 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated 2-Methyl-3-thioacetoxy-4,5-dihydrofuran?
Yes. JECFA number 1089, evaluated at the 59th meeting in 2002. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
How is 2-Methyl-3-thioacetoxy-4,5-dihydrofuran described, and where does it show up?
Flavorists describe 2-Methyl-3-thioacetoxy-4,5-dihydrofuran as sweet, fruity, tropical, sulfurous, herbal. It is used in beverage, confection, fruit flavors and savory dishes.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-METHYL-3-THIOACETOXY-4,5-DIHYDROFURAN under CAS 26486-14-6 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.