Flavor ingredient regulatory record
2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers
2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers is a natural complex flavoring material in the fruity family, FEMA GRAS under FEMA number 3972 (CAS 252736-39-3). Its odor is sweet, fruity, tropical, sulfurous, estery.
- FEMA
- 3972
- CAS
- 252736-39-3
- JECFA
- 1092
- EU FL
- 13.194
GRAS status: FEMA GRAS, publication 20. Recorded by FDA in the Substances Added to Food inventory under CAS 252736-39-3.
Structure
Material
2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers is a natural complex material rather than a single molecule, so it has no one structure. FEMA lists it as 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers.
Identity
Also known as: Ethanethioic acid, S-(tetrahydro-2,5-dimethyl-3-furanyl) ester, S-(Tetrahydro-2,5-dimethyl-3-furanyl) ethanethioate.
Can 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers is FEMA GRAS under FEMA number 3972. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 13.194, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1092.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, tropical, sulfurous, estery.
Where it is used
2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers is used in beverage, confection, fruit flavors and savory dishes, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Methyl-4-propyl-1,3-oxathiane | 3578 | 81% | In nature |
| 2-Methyl-3-thioacetoxy-4,5-dihydrofuran | 3636 | 75% | In nature |
| (+/-) 4-Methyl-2-propyl-1,3-oxathiane | 4677 | 75% | Not determined |
| 3-[(2-Methyl-3-furyl)thio]-2-butanone | 4056 | 59% | Not determined |
| 2-Ethanethoic acid, S-(2-methyl-3-furanyl) ester | 3973 | 55% | Not determined |
More thioesters in this index
Menthone-8-thioacetate · S-Furfuryl thioacetate · 2-Methyl-3-thioacetoxy-4,5-dihydrofuran · Propyl thioacetate · S-Methyl 2-methylbutanethioate
2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers FAQ
Is 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers FEMA GRAS?
Yes. The FEMA Expert Panel lists 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers as GRAS under FEMA number 3972. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers?
2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers is FEMA 3972, CAS 252736-39-3. FEMA files it in the fruity flavor category.
Is 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers on the EU Union List?
2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers is on the EU Union List of flavouring substances as FL 13.194 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers?
Yes. JECFA number 1092.
How is 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers described, and where does it show up?
Flavorists describe 2,5-Dimethyl-3-thioacetoxy-tetrahydrofuran, cis and trans isomers as sweet, fruity, tropical, sulfurous, estery. It is used in beverage, confection, fruit flavors and savory dishes.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as S-(TETRAHYDRO-2,5-DIMETHYL-3-FURANYL) ETHANETHIOATE under CAS 252736-39-3 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.