Flavor ingredient regulatory record
4-Acetyl-6-t-butyl-1,1-dimethylindan
4-Acetyl-6-t-butyl-1,1-dimethylindan is a ketone in the fruity family, FEMA GRAS under FEMA number 3653 (CAS 13171-00-1). Its odor is sweet, fruity, caramel, nutty, creamy.
- FEMA
- 3653
- CAS
- 13171-00-1
- JECFA
- 812
- Formula
- C17H24O
- EC
- 236-114-4
GRAS status: FEMA GRAS, publication 13. Recorded by FDA in the Substances Added to Food inventory under CAS 13171-00-1.
Structure
Identity
Also known as: Ethanone, 1-[6-(1,1-dimethylethyl)-2,3-dihydro-1,1-dimethyl-1H-inden-4-yl]-, Ketone, 6-tert-butyl-1,1-dimethyl-4-indanyl methyl, 1-[6-(1,1-Dimethylethyl)-2,3-dihydro-1,1-dimethyl-1H-inden-4-yl]ethanone, 4-Acetyl-1,1-dimethyl-6-tert-butylindan, 4-Acetyl-6-tert-butyl-1,1-dimethylindan, Celestolide, 4-Acetyl-6-tert-butyl-1,1-dimethylindane, Esperone, Crysolide, ADBI, 4-Acetyl-1,1-dimethyl-6-tert-butylindane, 6-tert-Butyl-1,1-dimethyl-4-indanyl methyl ketone.
Can 4-Acetyl-6-t-butyl-1,1-dimethylindan be labeled natural?
Nature makes 4-Acetyl-6-t-butyl-1,1-dimethylindan, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial 4-Acetyl-6-t-butyl-1,1-dimethylindan, same molecule. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
4-Acetyl-6-t-butyl-1,1-dimethylindan is FEMA GRAS under FEMA number 3653. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 4-Acetyl-6-t-butyl-1,1-dimethylindan. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 812, evaluated at the 57th meeting in 2001. Further data are required for a safety evaluation; this flavouring agent cannot be classified as of no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 4-Acetyl-6-t-butyl-1,1-dimethylindan appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 13171-00-1, where EPA names it Ethanone, 1-[6-(1,1-dimethylethyl)-2,3-dihydro-1,1-dimethyl-1H-inden-4-yl]-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, caramel, nutty, creamy.
Where it is used
4-Acetyl-6-t-butyl-1,1-dimethylindan is used in beverage, confection, bakery and dairy, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 4-Acetyl-6-t-butyl-1,1-dimethylindan by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| beta-Isomethylionone | 4151 | 70% | In nature |
| alpha-iso-Methylionone | 2714 | 69% | In nature |
| 2,6-Dimethyl-3-[(2-methyl-3-furyl)thio]-4-heptanone | 3538 | 68% | In nature |
| beta-Ionol | 3625 | 68% | In nature |
| beta-Ionone | 2595 | 67% | In nature |
More ketones in this index
3-Penten-2-one · 1-(4-Methoxyphenyl)-4-methyl-1-penten-3-one · 4-Acetyl-2-methylpyrimidine · 3-Hexanone · cis-1-(2,6,6-Trimethyl-2-cyclohexenyl)-2-butenone · 2,6-Dimethyl-4-heptanone
4-Acetyl-6-t-butyl-1,1-dimethylindan FAQ
Is 4-Acetyl-6-t-butyl-1,1-dimethylindan on the FEMA GRAS list?
It is. FEMA number 3653 covers 4-Acetyl-6-t-butyl-1,1-dimethylindan. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for 4-Acetyl-6-t-butyl-1,1-dimethylindan?
The FEMA number for 4-Acetyl-6-t-butyl-1,1-dimethylindan is 3653 and its CAS registry number is 13171-00-1. Its flavor category is fruity.
What is 4-Acetyl-6-t-butyl-1,1-dimethylindan used for?
4-Acetyl-6-t-butyl-1,1-dimethylindan is described as sweet, fruity, caramel, nutty, creamy. It shows up in beverage, confection, bakery and dairy.
What did JECFA conclude about 4-Acetyl-6-t-butyl-1,1-dimethylindan?
JECFA evaluated 4-Acetyl-6-t-butyl-1,1-dimethylindan at the 57th meeting in 2001 under JECFA number 812. The panel concluded: Further data are required for a safety evaluation; this flavouring agent cannot be classified as of no safety concern at current levels of intake.
Is 4-Acetyl-6-t-butyl-1,1-dimethylindan approved in the EU?
No EU FL number is on file for 4-Acetyl-6-t-butyl-1,1-dimethylindan. It has a JECFA evaluation (JECFA 812), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Is 4-Acetyl-6-t-butyl-1,1-dimethylindan natural or artificial?
The process decides for 4-Acetyl-6-t-butyl-1,1-dimethylindan. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic 4-Acetyl-6-t-butyl-1,1-dimethylindan is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 4-ACETYL-6-TERT-BUTYL-1,1-DIMETHYLINDANE under CAS 13171-00-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.