Flavor ingredient regulatory record
beta-Ionol
beta-Ionol is a terpene in the floral family, FEMA GRAS under FEMA number 3625 (CAS 22029-76-1). Its odor is floral, sweet, violet, rosy, earthy.
- FEMA
- 3625
- CAS
- 22029-76-1
- JECFA
- 392
- EU FL
- 02.106
- Formula
- C13H22O
- EC
- 244-735-7
GRAS status: FEMA GRAS, publication 12. Recorded by FDA in the Substances Added to Food inventory under CAS 22029-76-1.
Structure
Identity
Also known as: 3-Buten-2-ol, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, 4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-ol, β-Ionol, ionol, beta-, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-ol, beta-lonol, ionol,beta, 2-hydroxy-beta-ionone, trans-beta-ionol, 3-buten-2-ol, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (e)-4-(2,6,6-trimethylcyclohexen-1-yl)but-3-en-2-ol, beta-ionol, (e)-.
Can beta-Ionol be labeled natural?
Nature makes beta-Ionol, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial beta-Ionol, same molecule. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
beta-Ionol is FEMA GRAS under FEMA number 3625. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 02.106, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
Purity. At least 92%; secondary components 3-8% ionol and ionone
JECFA (WHO / FAO)
JECFA number 392, evaluated at the 51st meeting in 1998. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. beta-Ionol appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 22029-76-1, where EPA names it 3-Buten-2-ol, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Floral, sweet, violet, rosy, earthy.
Taste: Floral, sweet, slightly bitter.
Where it is used
beta-Ionol is used in fragrance, beverage, confection and floral flavors, typically as a floral note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to beta-Ionol by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| alpha-Ionol | 3624 | 98% | In nature |
| Dihydro-beta-ionol | 3627 | 93% | In nature |
| beta-Ionone | 2595 | 91% | In nature |
| alpha-Ionone | 2594 | 90% | In nature |
| Dehydrodihydroionone | 3447 | 89% | In nature |
More terpenes in this index
Linalool oxide pyranoid · (+/-)-Dihydrofarnesol · alpha-Ionol · alpha -Bisabolene · beta-Bisabolene · alpha-Irone
beta-Ionol FAQ
Does beta-Ionol have FEMA GRAS status?
beta-Ionol holds FEMA GRAS status under FEMA number 3625. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite beta-Ionol by FEMA or CAS number?
Cite beta-Ionol as FEMA 3625 or CAS 22029-76-1; both point to the same entry. Its flavor category is floral.
What does beta-Ionol smell and taste like, and where is it used?
The odor of beta-Ionol is floral, sweet, violet, rosy, earthy. On the palate it is floral, sweet, slightly bitter. Typical uses are fragrance, beverage, confection and floral flavors.
What did JECFA conclude about beta-Ionol?
JECFA evaluated beta-Ionol at the 51st meeting in 1998 under JECFA number 392. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Can beta-Ionol be used in the EU and UK?
Yes. FL 02.106 is the Union List entry for beta-Ionol, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Can beta-Ionol be labeled a natural flavor?
The process decides for beta-Ionol. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic beta-Ionol is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as BETA-IONOL under CAS 22029-76-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.