Flavor ingredient regulatory record
4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one
4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one is a heterocyclic compound in the earthy family, FEMA GRAS under FEMA number 4669 (CAS 121746-18-7). Its odor is earthy, herbal, slightly bitter, musty.
- FEMA
- 4669
- CAS
- 121746-18-7
- JECFA
- 2117
- EU FL
- 16.116
GRAS status: FEMA GRAS, publication 25. Recorded by FDA in the Substances Added to Food inventory under CAS 121746-18-7.
Structure
Under review
The structure for 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: 4-amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1h)-one, 4-amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1h)-one, 4-amino-5,6-dimethyl-1h,2h-thieno[2,3-d]pyrimidin-2-one, 4-amino-5,6-dimethyl-3h-thieno[2,3-d]pyrimidin-2-one, 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1h)-one.
Can 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one is FEMA GRAS under FEMA number 4669. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.116, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 2117, evaluated at the 76th meeting in 2012. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Earthy, herbal, slightly bitter, musty.
Taste: Umami, slightly bitter, savory.
Where it is used
4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one is used in savory dishes, seasonings, snacks and sauces, typically as a earthy note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Skatole | 3019 | 72% | In nature |
| Indole | 2593 | 68% | In nature |
| 2-Propionylpyrrole | 3614 | 63% | Not determined |
| Theobromine | 3591 | 62% | In nature |
| Methyl 2-pyrrolyl ketone | 3202 | 61% | In nature |
More heterocyclic compounds in this index
4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one FAQ
Does 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one have FEMA GRAS status?
4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one holds FEMA GRAS status under FEMA number 4669. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one by FEMA or CAS number?
Cite 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one as FEMA 4669 or CAS 121746-18-7; both point to the same entry. Its flavor category is earthy.
What does 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one smell and taste like, and where is it used?
The odor of 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one is earthy, herbal, slightly bitter, musty. On the palate it is umami, slightly bitter, savory. Typical uses are savory dishes, seasonings, snacks and sauces.
What did JECFA conclude about 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one?
JECFA evaluated 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one at the 76th meeting in 2012 under JECFA number 2117. The panel concluded: no safety concern at current levels of intake.
Can 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one be used in the EU and UK?
Yes. FL 16.116 is the Union List entry for 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 4-AMINO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-2(1H)-ONE under CAS 121746-18-7 and carries its FEMA number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.