Flavor ingredient regulatory record
4-Methylidene-2-(2-methylprop-1-enyl)oxane
4-Methylidene-2-(2-methylprop-1-enyl)oxane is a terpene in the fruity family, FEMA GRAS under FEMA number 4929 (CAS 60857-05-8). Its odor is sweet, fruity, citrus, herbal, green.
- FEMA
- 4929
- CAS
- 60857-05-8
- Formula
- C10H16O
GRAS status: FEMA GRAS. Source: FEMA Flavor Ingredient Library.
Structure
Identity
Also known as: 2H-Pyran, tetrahydro-4-methylene-2-(2-methyl-1-propen-1-yl)-, 2H-Pyran, tetrahydro-4-methylene-2-(2-methyl-1-propenyl)-, Tetrahydro-4-methylene-2-(2-methyl-1-propen-1-yl)-2H-pyran, 2-(2-Methylprop-1-enyl)4-methylenetetrahydropyran, 2h-pyran, tetrahydro-4-methylene-2-(2-methyl-1-propenyl)-, tetrahydro-4-methylene-2-(2-methyl-1-propenyl)-2h-pyran, 2h-pyran, tetrahydro-4-methylene-2-(2-methyl-1-propen-1-yl)-, 2-(2-methylprop-1-enyl)4-methylenetetrahydropyran, tetrahydro-4-methylene-2-(2-methyl-1-propen-1-yl)-2h-pyran, 4-methylidene-2-(2-methylprop-1-en-1-yl)oxane, db-321734, 2-(2-methylprop-1-enyl)4-methylenetetrahydropyran, (+/-)-.
Can 4-Methylidene-2-(2-methylprop-1-enyl)oxane be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
4-Methylidene-2-(2-methylprop-1-enyl)oxane is FEMA GRAS under FEMA number 4929. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 4-Methylidene-2-(2-methylprop-1-enyl)oxane. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
4-Methylidene-2-(2-methylprop-1-enyl)oxane has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 4-Methylidene-2-(2-methylprop-1-enyl)oxane appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 60857-05-8, where EPA names it 2H-Pyran, tetrahydro-4-methylene-2-(2-methyl-1-propen-1-yl)-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, citrus, herbal, green.
Where it is used
4-Methylidene-2-(2-methylprop-1-enyl)oxane is used in beverage, confection, flavoring and snacks, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 4-Methylidene-2-(2-methylprop-1-enyl)oxane by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Nerol oxide | 3661 | 90% | In nature |
| Isopulegone | 2964 | 82% | In nature |
More terpenes in this index
2,2,6-Trimethyl-6-vinyltetrahydropyran · Farnesene · 10-Hydroxymethylene-2-pinene · beta-Farnesene · Verbenol · Carveol
4-Methylidene-2-(2-methylprop-1-enyl)oxane FAQ
Is 4-Methylidene-2-(2-methylprop-1-enyl)oxane FEMA GRAS?
Yes. The FEMA Expert Panel lists 4-Methylidene-2-(2-methylprop-1-enyl)oxane as GRAS under FEMA number 4929. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for 4-Methylidene-2-(2-methylprop-1-enyl)oxane?
4-Methylidene-2-(2-methylprop-1-enyl)oxane is FEMA 4929, CAS 60857-05-8. Its flavor category is fruity.
How is 4-Methylidene-2-(2-methylprop-1-enyl)oxane described, and where does it show up?
Flavorists describe 4-Methylidene-2-(2-methylprop-1-enyl)oxane as sweet, fruity, citrus, herbal, green. It is used in beverage, confection, flavoring and snacks.
Ingredient lookup
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
Check 4-Methylidene-2-(2-methylprop-1-enyl)oxane in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The FEMA number and GRAS status on this page name a conclusion reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States. FDA does not list this substance by FEMA number in its Substances Added to Food inventory. Its identity is attested by EPA TSCA Chemical Substance Inventory, matched on CAS 60857-05-8.
FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.