Flavor ingredient regulatory record
Caryophyllene alcohol
Caryophyllene alcohol is a terpene in the spice family, FEMA GRAS under FEMA number 4410 (CAS 56747-96-7). Its odor is spicy, woody, earthy, herbal.
- FEMA
- 4410
- CAS
- 56747-96-7
- JECFA
- 2027
- Formula
- C15H26O
- EC
- 260-364-3
GRAS status: FEMA GRAS, publication 23. Recorded by FDA in the Substances Added to Food inventory under CAS 4586-22-5.
Structure
Identity
Also known as: caryolan-1-ol, tricyclo(6.3.1.02,5)dodecan-1-ol, 4,4,8-trimethyl-, (1r,2s,5r,8s)-, tricyclo(6.3.1.0(sup 2,5))dodecan-1-ol, 4,4,8-trimethyl-, (1r-(1-alpha,2-alpha,5-beta,8beta))-, tricyclo(6.3.1.0(sup 2,5))dodecan-1-ol, 4,4,8-trimethyl-, stereoisomer, .beta.-caryophyllene alcohol, caryophyllene alcohol, beta-, caryolanol-1, .beta.-caryolanol, tricyclo(6.3.1.02,5)dodecan-1-ol, 4,4,8-trimethyl-, 4,4,8-trimethyltricyclo(6.3.1.02,5)dodecan-1-ol, stereoisomer, caryophyllene alcohol [fhfi], tricyclo(6.3.1.02,5)dodecan-1-ol, 4,4,8-trimethyl-, stereoisomer.
Can Caryophyllene alcohol be labeled natural?
Since caryophyllene alcohol is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when caryophyllene alcohol is synthesized. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Caryophyllene alcohol is FEMA GRAS under FEMA number 4410. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Caryophyllene alcohol. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2027.
Other US flags
Not on the California Proposition 65 list. Listed on the EPA TSCA inventory.
Odor and taste
Odor: Spicy, woody, earthy, herbal.
Taste: Bitter, spicy, warm.
Where it is used
Caryophyllene alcohol is used in beverage, savory dishes, seasonings and confection, typically as a spice note.
More terpenes in this index
beta-Caryophyllene oxide · dl-Camphor · Caryophylla-3(4),8-dien-5-ol · Thujyl alcohol · p-Mentha-1,8-dien-7-ol · (-)-Sclareol
Caryophyllene alcohol FAQ
Is caryophyllene alcohol FEMA GRAS?
Yes. The FEMA Expert Panel lists caryophyllene alcohol as GRAS under FEMA number 4410. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for caryophyllene alcohol?
Caryophyllene alcohol is FEMA 4410, CAS 56747-96-7. FEMA files it in the spice flavor category.
Does caryophyllene alcohol count as natural in the US and the EU?
Caryophyllene alcohol occurs in nature, so the label depends on the route: caryophyllene alcohol won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized caryophyllene alcohol is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic caryophyllene alcohol identical-to-natural.
Is caryophyllene alcohol approved in the EU?
No EU FL number is on file for caryophyllene alcohol. It has a JECFA evaluation (JECFA 2027), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated caryophyllene alcohol?
Yes. JECFA number 2027.
How is caryophyllene alcohol described, and where does it show up?
Flavorists describe caryophyllene alcohol as spicy, woody, earthy, herbal. On the palate it is bitter, spicy, warm. It is used in beverage, savory dishes, seasonings and confection.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as CARYOPHYLLENE ALCOHOL under CAS 4586-22-5 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.