Flavor ingredient regulatory record
Cyclohexanone diethyl ketal
Cyclohexanone diethyl ketal is a ketone in the fruity family, FEMA GRAS under FEMA number 4516 (CAS 1670-47-9). Its odor is sweet, fruity, floral, estery, creamy.
- FEMA
- 4516
- CAS
- 1670-47-9
- JECFA
- 2051
- Formula
- C10H20O2
- EC
- 216-798-0
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 1670-47-9.
Structure
Identity
Also known as: Cyclohexane, 1,1-diethoxy-, Cyclohexanone, diethyl acetal, 1,1-Diethoxycyclohexane, 1,1-diethoxycyclohexane, cyclohexanone diethyl acetal, cyclohexane, 1,1-diethoxy-, diethoxycyclohexane, cyclohexanone diethylketal, 1,1-diethoxy cyclohexane, 1,1-diethoxy-cyclohexane, cyclohexanone, diethyl acetal, cyclohexanone diethyl ketal, 97%.
Can Cyclohexanone diethyl ketal be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Cyclohexanone diethyl ketal is FEMA GRAS under FEMA number 4516. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Cyclohexanone diethyl ketal. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2051, evaluated at the 64th meeting in 2005. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Cyclohexanone diethyl ketal appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 1670-47-9, where EPA names it Cyclohexane, 1,1-diethoxy-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, floral, estery, creamy.
Where it is used
Cyclohexanone diethyl ketal is used in beverage, confection, flavoring, bakery and dairy, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Cyclohexanone diethyl ketal by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2,5-Diethyltetrahydrofuran | 3743 | 82% | In nature |
| 1,1-Dipropoxyethane | 4688 | 78% | Not determined |
| Heptanal propyleneglycol acetal | 4368 | 64% | Not determined |
| 2-Butyrylfuran | 4083 | 62% | In nature |
| S-Methyl benzothioate | 3857 | 61% | In nature |
More ketones in this index
Methylcyclopentenolone · 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one · 5-Methyl-5-hexen-2-one · 3-(hydroxymethyl)-2-heptanone · 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one · 10-Undecen-2-one
Cyclohexanone diethyl ketal FAQ
Does cyclohexanone diethyl ketal have FEMA GRAS status?
Cyclohexanone diethyl ketal holds FEMA GRAS status under FEMA number 4516. It is also codified at 21 CFR 172.515.
How do I cite cyclohexanone diethyl ketal by FEMA or CAS number?
Cite cyclohexanone diethyl ketal as FEMA 4516 or CAS 1670-47-9; both point to the same entry. FEMA files it in the fruity flavor category.
Is cyclohexanone diethyl ketal approved in the EU?
No EU FL number is on file for cyclohexanone diethyl ketal. It has a JECFA evaluation (JECFA 2051), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated cyclohexanone diethyl ketal?
Yes. JECFA number 2051, evaluated at the 64th meeting in 2005. Conclusion: no safety concern at current levels of intake.
What does cyclohexanone diethyl ketal smell and taste like, and where is it used?
The odor of cyclohexanone diethyl ketal is sweet, fruity, floral, estery, creamy. Typical uses are beverage, confection, flavoring, bakery and dairy.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as CYCLOHEXANONE DIETHYL KETAL under CAS 1670-47-9 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.