Flavor ingredient regulatory record
Furfural propyleneglycol acetal
Furfural propyleneglycol acetal is a furan in the fruity family, FEMA GRAS under FEMA number 4537 (CAS 4359-54-0). Its odor is sweet, caramel, nutty, toasted, vanilla.
- FEMA
- 4537
- CAS
- 4359-54-0
- JECFA
- 2100
- Formula
- C8H10O3
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 4359-54-0.
Structure
Identity
Also known as: 1,3-Dioxolane, 2-(2-furanyl)-4-methyl-, 1,3-Dioxolane, 2-(2-furyl)-4-methyl-, 2-(2-Furanyl)-4-methyl-1,3-dioxolane, NSC 75455, 1,3-dioxolane, 2-(2-furanyl)-4-methyl-, furfural propylene glycol acetal, 2-(2-furyl)-4-methyl-1,3-dioxolane, ai3-22421, 1,3-dioxolane, 2-(2-furyl)-4-methyl-, (+-)-2-(2-furyl)-4-methyl-1,3-dioxolane, 2-(2-furyl)-4-methyl-1,3-dioxolane, (+-)-, 2-(furan-2-yl)-4-methyl-1,3-dioxolane.
Can Furfural propyleneglycol acetal be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Furfural propyleneglycol acetal is FEMA GRAS under FEMA number 4537. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Furfural propyleneglycol acetal. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
Other US flags
Not on the California Proposition 65 list. Listed on the EPA TSCA inventory.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Furfural propyleneglycol acetal appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 4359-54-0, where EPA names it 1,3-Dioxolane, 2-(2-furanyl)-4-methyl-.
Inactive in US commerce
EPA designates this substance inactive, so a Notice of Activity Form B is required before anyone manufactures or processes it again. Being FEMA GRAS does not change that. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, caramel, nutty, toasted, vanilla.
Taste: Sweet, nutty, slightly roasted.
Where it is used
Furfural propyleneglycol acetal is used in beverage, confection, bakery, flavoring and desserts, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Furfural propyleneglycol acetal by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Ethyl furfuryl ether | 4114 | 87% | In nature |
| 2-Butyrylfuran | 4083 | 75% | In nature |
| 2-Butylfuran | 4081 | 72% | In nature |
| Furfuryl acetate | 2490 | 71% | In nature |
| Furfuryl methyl ether | 3159 | 64% | In nature |
More furans in this index
Furfural · 2-Acetyl-5-methylfuran · 2-Decylfuran · 2-Butyrylfuran · 2-Acetyl-3,5-dimethylfuran · 2,2'-(Thiodimethylene)difuran
Furfural propyleneglycol acetal FAQ
Does furfural propyleneglycol acetal have FEMA GRAS status?
Furfural propyleneglycol acetal holds FEMA GRAS status under FEMA number 4537. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite furfural propyleneglycol acetal by FEMA or CAS number?
Cite furfural propyleneglycol acetal as FEMA 4537 or CAS 4359-54-0; both point to the same entry. Its flavor category is fruity.
What does furfural propyleneglycol acetal smell and taste like, and where is it used?
The odor of furfural propyleneglycol acetal is sweet, caramel, nutty, toasted, vanilla. On the palate it is sweet, nutty, slightly roasted. Typical uses are beverage, confection, bakery, flavoring and desserts.
What did JECFA conclude about furfural propyleneglycol acetal?
JECFA evaluated furfural propyleneglycol acetal at the 76th meeting in 2012 under JECFA number 2100.
Is furfural propyleneglycol acetal approved in the EU?
No EU FL number is on file for furfural propyleneglycol acetal. It has a JECFA evaluation (JECFA 2100), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as FURFURAL PROPYLENEGLYCOL ACETAL under CAS 4359-54-0 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.