Flavor ingredient regulatory record
Glycyrrhizic acid, ammoniated
Glycyrrhizic acid, ammoniated is an acid in the sweet family, FEMA GRAS under FEMA number 2528 (CAS 53956-04-0). Its odor is sweet, licorice, herbal, earthy.
- FEMA
- 2528
- CAS
- 53956-04-0
- EU FL
- 16.060
- Formula
- C42H65NO16
- EC
- 258-887-7
GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 53956-04-0.
Structure
Identity
Also known as: α-D-Glucopyranosiduronic acid, (3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-, ammonium salt (1:1), α-D-Glucopyranosiduronic acid, (3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-, monoammonium salt, 30-Noroleanane, α-D-glucopyranosiduronic acid deriv., Ammonium glycyrrhizinate, Glycyrrhizic acid ammonium salt, Glycyrrhizin ammonium salt, Monoammonium glycyrrhizinate, Glycyrram, Glycamil, 18β-Glycyrrhizic acid monoammonium salt, Monoammonium glycyrrhizate, Glycyrrhizin monoammonium salt.
Can Glycyrrhizic acid, ammoniated be labeled natural?
Glycyrrhizic acid, ammoniated occurs in nature, so the label depends on the route: glycyrrhizic acid, ammoniated won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized glycyrrhizic acid, ammoniated is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic glycyrrhizic acid, ammoniated identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Glycyrrhizic acid, ammoniated is FEMA GRAS under FEMA number 2528. It is cited in the Code of Federal Regulations at 21 CFR 184.1408.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.060, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list. The entry carries use restrictions.
Use restrictions. In category 1 - not more than 40 mg/kg In category 3 - not more than 90 mg/kg In category 5 - not more than 1 500 mg/kg In category 5.3 - not more than 5 000 mg/kg In category 6 - not more than 45 mg/kg In categories 7 and 13 - not more than 60 mg/kg In category 9 - not more than 300 mg/kg In category 11 - not more than 100 mg/kg In category 12 - not more than 50 mg/kg In categories 14.1 and 14.2 - not more than 200 mg/kg In category 15 - not more than 150 mg/kg
JECFA (WHO / FAO)
Glycyrrhizic acid, ammoniated has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Glycyrrhizic acid, ammoniated appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 53956-04-0, where EPA names it .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, ammonium salt (1:1).
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, licorice, herbal, earthy.
Taste: Sweet, bitter, herbal.
Where it is used
Glycyrrhizic acid, ammoniated is used in beverage, confection, herbal products and flavoring agents, typically as a sweet note.
More acids in this index
Lauric acid · Sodium Gluconate · (E,Z)-4-Methylpent-2-enoic acid · 4-Hydroxybenzoic acid · Heptanoic acid · 2-Oxobutyric acid
Glycyrrhizic acid, ammoniated FAQ
Is glycyrrhizic acid, ammoniated on the FEMA GRAS list?
It is. FEMA number 2528 covers glycyrrhizic acid, ammoniated. It is also codified at 21 CFR 184.1408.
What is the FEMA number for glycyrrhizic acid, ammoniated?
The FEMA number for glycyrrhizic acid, ammoniated is 2528 and its CAS registry number is 53956-04-0. FEMA files it in the sweet flavor category.
Is glycyrrhizic acid, ammoniated natural or artificial?
Since glycyrrhizic acid, ammoniated is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when glycyrrhizic acid, ammoniated is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic glycyrrhizic acid, ammoniated identical-to-natural.
Is glycyrrhizic acid, ammoniated approved in the EU?
Glycyrrhizic acid, ammoniated is on the EU Union List of flavouring substances as FL 16.060 (Annex I Part A) under Regulation 1334/2008. Its entry carries use restrictions, listed on this page.
What is glycyrrhizic acid, ammoniated used for?
Glycyrrhizic acid, ammoniated is described as sweet, licorice, herbal, earthy. On the palate it is sweet, bitter, herbal. It shows up in beverage, confection, herbal products and flavoring agents.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) under CAS 53956-04-0 and carries its FEMA number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.