Flavor ingredient regulatory record
Sodium Gluconate
Sodium Gluconate is an acid in the sweet family, FEMA GRAS under FEMA number 4934 (CAS 527-07-1). Its odor is slightly sweet, mild, clean, neutral.
- FEMA
- 4934
- CAS
- 527-07-1
- Formula
- C6H11NaO7
- EC
- 208-407-7
GRAS status: FEMA GRAS. Source: FEMA Flavor Ingredient Library.
Structure
Identity
Also known as: D-Gluconic acid, sodium salt (1:1), Gluconic acid, monosodium salt, D-, D-Gluconic acid, monosodium salt, Glonsen, Pasexon 100T, Gluconic acid sodium salt, PMP Sodium Gluconate, Gluconic acid monosodium salt, Monosodium gluconate, Sunmorl N 60S, Clewat GL, Disparlight DV.
Can Sodium Gluconate be labeled natural?
Since Sodium Gluconate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when Sodium Gluconate is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Sodium Gluconate is FEMA GRAS under FEMA number 4934. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Sodium Gluconate. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
Sodium Gluconate has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Sodium Gluconate appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 527-07-1, where EPA names it D-Gluconic acid, sodium salt (1:1).
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Slightly sweet, mild, clean, neutral.
Taste: Slightly sweet, mild, neutral.
Where it is used
Sodium Gluconate is used in food preservative, flavor enhancer, baked goods, beverages and seasonings, typically as a sweet note.
More acids in this index
Glycyrrhizic acid, ammoniated · Lauric acid · Undecanoic acid · 2-Methylheptanoic acid · 3,7-Dimethyl-6-octenoic acid · Sodium diacetate
Sodium Gluconate FAQ
Is Sodium Gluconate on the FEMA GRAS list?
It is. FEMA number 4934 covers Sodium Gluconate. It is also codified at 21 CFR 172.515.
What is the FEMA number for Sodium Gluconate?
The FEMA number for Sodium Gluconate is 4934 and its CAS registry number is 527-07-1. FEMA files it in the sweet flavor category.
Is Sodium Gluconate natural or artificial?
Sodium Gluconate occurs in nature, so the label depends on the route: Sodium Gluconate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized Sodium Gluconate is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
What is Sodium Gluconate used for?
Sodium Gluconate is described as slightly sweet, mild, clean, neutral. On the palate it is slightly sweet, mild, neutral. It shows up in food preservative, flavor enhancer, baked goods, beverages and seasonings.
Ingredient lookup
Check an ingredient
Start typing to search the ingredient corpus.
Or browse every ingredient page, A to Z.
Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
Check Sodium Gluconate in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The FEMA number and GRAS status on this page name a conclusion reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States. FDA does not list this substance by FEMA number in its Substances Added to Food inventory. Its identity is attested by FDA Substances Added to Food, EPA TSCA Chemical Substance Inventory, matched on CAS 527-07-1.
FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.