Flavor ingredient regulatory record
Guaiacol isobutyrate
Guaiacol isobutyrate is an ester in the fruity family, FEMA GRAS under FEMA number 4608 (CAS 723759-62-4). Its odor is sweet, fruity, vanilla, creamy, floral.
- FEMA
- 4608
- CAS
- 723759-62-4
- JECFA
- 2016
- EU FL
- 09.945
- Formula
- C11H14O3
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 723759-62-4.
Structure
Identity
Also known as: 2-methoxyphenyl isobutyrate, 2-methoxyphenyl-2-methyl propanoate, propanoic acid, 2-methyl-, 2-methoxyphenyl ester, guaiacyl isobutyrate, 2-methoxyphenyl 2-methylpropanoate, (2-methoxyphenyl) 2-methylpropanoate, isobutyric acid 2-methoxyphenyl ester.
Can Guaiacol isobutyrate be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Guaiacol isobutyrate is FEMA GRAS under FEMA number 4608. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.945, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 2016.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, vanilla, creamy, floral.
Where it is used
Guaiacol isobutyrate is used in beverage, confection, dairy, bakery and flavoring, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Guaiacol isobutyrate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Guaiacol propionate | 4609 | 87% | In nature |
| Ethyl maltol isobutyrate | 4534 | 85% | Not determined |
| Guaiacol butyrate | 4607 | 81% | Not determined |
| Vanillin isobutyrate | 3754 | 81% | In nature |
| Ethyl vanillin isobutyrate | 3837 | 76% | In nature |
More esters in this index
Isopropyl myristate · trans-2-Octen-1-yl butanoate · Benzyl acetoacetate · cis-3-Hexenyl acetoacetate · 6-[5(6)-Decenoyloxy]decanoic acid · (E)-2-Hexenyl octanoate
Guaiacol isobutyrate FAQ
Is guaiacol isobutyrate FEMA GRAS?
Yes. The FEMA Expert Panel lists guaiacol isobutyrate as GRAS under FEMA number 4608. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for guaiacol isobutyrate?
Guaiacol isobutyrate is FEMA 4608, CAS 723759-62-4. FEMA files it in the fruity flavor category.
Is guaiacol isobutyrate on the EU Union List?
Guaiacol isobutyrate is on the EU Union List of flavouring substances as FL 09.945 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated guaiacol isobutyrate?
Yes. JECFA number 2016.
How is guaiacol isobutyrate described, and where does it show up?
Flavorists describe guaiacol isobutyrate as sweet, fruity, vanilla, creamy, floral. It is used in beverage, confection, dairy, bakery and flavoring.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as GUAIACYL ISOBUTYRATE under CAS 723759-62-4 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.