Flavor ingredient regulatory record
Methylthio 2-(propionyloxy)propionate
Methylthio 2-(propionyloxy)propionate is an ester in the fruity family, FEMA GRAS under FEMA number 3790 (CAS 827024-53-3). Its odor is sweet, fruity, tropical, estery, apple.
- FEMA
- 3790
- CAS
- 827024-53-3
- JECFA
- 493
- EU FL
- 12.227
GRAS status: FEMA GRAS, publication 16. Recorded by FDA in the Substances Added to Food inventory under CAS 977161-96-8.
Structure
Under review
The structure for Methylthio 2-(propionyloxy)propionate is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: methylthio 2-(propionyloxy) propionate, propionyllactic acid thiomethyl ester, methyl thiopropionyl oxypropionate, s-methyl 2-(propionyloxy)propanethioate, propanethioic acid, 2-(1-oxopropoxy)-, s-methyl ester, methylthio 2-(propionyloxy) propionate [fhfi], methylthio 2-(propanoyloxy)propanoate, s-methyl-2-(propionyloxy)propanethioate, (1-methylsulanyl-1-oxopropan-2-yl) propanoate, 1-(methylsulfanyl)-1-oxopropan-2-yl propanoate.
Can Methylthio 2-(propionyloxy)propionate be labeled natural?
Since methylthio 2-(propionyloxy)propionate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when methylthio 2-(propionyloxy)propionate is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic methylthio 2-(propionyloxy)propionate identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Methylthio 2-(propionyloxy)propionate is FEMA GRAS under FEMA number 3790. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 12.227, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 493, evaluated at the 53rd meeting in 1999. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, tropical, estery, apple.
Where it is used
Methylthio 2-(propionyloxy)propionate is used in beverage, confection, fruit flavors, bakery and desserts, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Methylthio 2-(propionyloxy)propionate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Butan-3-one-2-yl butanoate | 3332 | 81% | In nature |
More esters in this index
1-Octen-3-yl acetate · 3-Hexenyl 3-methylbutanoate · 3-Oxododecanoic acid glyceride · Butan-3-one-2-yl butanoate · 1-Isobutoxy-1-ethoxyethane · Methyl thiobutyrate
Methylthio 2-(propionyloxy)propionate FAQ
Does methylthio 2-(propionyloxy)propionate have FEMA GRAS status?
Methylthio 2-(propionyloxy)propionate holds FEMA GRAS status under FEMA number 3790. It is also codified at 21 CFR 172.515.
How do I cite methylthio 2-(propionyloxy)propionate by FEMA or CAS number?
Cite methylthio 2-(propionyloxy)propionate as FEMA 3790 or CAS 827024-53-3; both point to the same entry. FEMA files it in the fruity flavor category.
Can methylthio 2-(propionyloxy)propionate be labeled a natural flavor?
Methylthio 2-(propionyloxy)propionate occurs in nature, so the label depends on the route: methylthio 2-(propionyloxy)propionate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized methylthio 2-(propionyloxy)propionate is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Can methylthio 2-(propionyloxy)propionate be used in the EU and UK?
Methylthio 2-(propionyloxy)propionate is on the EU Union List of flavouring substances as FL 12.227 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated methylthio 2-(propionyloxy)propionate?
Yes. JECFA number 493, evaluated at the 53rd meeting in 1999. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What does methylthio 2-(propionyloxy)propionate smell and taste like, and where is it used?
The odor of methylthio 2-(propionyloxy)propionate is sweet, fruity, tropical, estery, apple. Typical uses are beverage, confection, fruit flavors, bakery and desserts.
Ingredient lookup
Check an ingredient
Start typing to search the ingredient corpus.
Or browse every ingredient page, A to Z.
Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
Check Methylthio 2-(propionyloxy)propionate in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as METHYLTHIO 2-(PROPIONYLOXY)PROPIONATE under CAS 977161-96-8 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.