Flavor ingredient regulatory record
2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone
2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone is a lactone in the fruity family, FEMA GRAS under FEMA number 4270 (CAS 5617-64-1).
- FEMA
- 4270
- CAS
- 5617-64-1
- JECFA
- 2224
GRAS status: FEMA GRAS, publication 23. Recorded by FDA in the Substances Added to Food inventory under CAS 5617-64-1.
Structure
Under review
The structure for 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: coumane, benzo(b)cyclopropa(d)pyran-2(1ah)-one, 1,7b-dihydro-, 2-(2-hydroxyphenyl) cyclopropanecarboxylic delta-lactone [fhfi], cyclopropanecarboxylic acid, 2-(2-hydroxyphenyl)-, delta-lactone, 2-(2-hydroxyphenyl)cyclopropanecarboxylic acid .delta.-lactone, 2-(2-hydroxyphenyl) cyclopropanecarboxylic .delta.-lactone [fhfi], cyclopropanecarboxylic acid, 2-(2-hydroxyphenyl)-, .delta.-lactone, (+-)-coumane, coumane, (+-)-, 2-(2-hydroxyphenyl) cyclopropanecarboxylic delta-lactone, 2-(2-hydroxyphenyl)cyclopropanecarboxylic acid delta-lactone, cyclopropylcoumarin.
Can 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone be labeled natural?
Since 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone is FEMA GRAS under FEMA number 4270. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2224, evaluated at the 64th meeting in 2005. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Taste: Sweet, creamy, slightly tart.
Where it is used
2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone is used in beverage, confection, dairy, fruit flavors and bakery, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Dihydrocoumarin | 2381 | 78% | In nature |
| Ethyl 3-phenyl-2,3-epoxypropionate | 2454 | 55% | In nature |
| Epoxy oxophorone | 4109 | 51% | In nature |
| Piperitenone oxide | 4199 | 38% | In nature |
| trans-Carvone-5,6-oxide | 4084 | 37% | In nature |
More lactones in this index
5-Hydroxy-2,4-decadienoic acid delta-lactone · 5-Hydroxy-8-undecenoic acid delta-lactone · delta-Octalactone · (+/-) 3-Methyl-gamma-decalactone · Dihydrocoumarin · 4,4-Dibutyl-gamma-butyrolactone
2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone FAQ
Does 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone have FEMA GRAS status?
2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone holds FEMA GRAS status under FEMA number 4270. It is also codified at 21 CFR 172.515.
How do I cite 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone by FEMA or CAS number?
Cite 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone as FEMA 4270 or CAS 5617-64-1; both point to the same entry. FEMA files it in the fruity flavor category.
Can 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone be labeled a natural flavor?
2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone occurs in nature, so the label depends on the route: 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Is 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone approved in the EU?
No EU FL number is on file for 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone. It has a JECFA evaluation (JECFA 2224), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated 2-(2-Hydroxyphenyl)-cyclopropanecarbocyclic acid delta-lactone?
Yes. JECFA number 2224, evaluated at the 64th meeting in 2005. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-(2-HYDROXYPHENYL) CYCLOPROPANECARBOXYLIC ACID DELTA LACTONE under CAS 5617-64-1 and carries its FEMA number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.