Flavor ingredient regulatory record
trans-Carvone-5,6-oxide
trans-Carvone-5,6-oxide is a terpene in the fruity family, FEMA GRAS under FEMA number 4084 (CAS 18383-49-8). Its odor is sweet, minty, herbal, green, fresh.
- FEMA
- 4084
- CAS
- 18383-49-8
- JECFA
- 1572
- Formula
- C10H14O2
GRAS status: FEMA GRAS, publication 22. Recorded by FDA in the Substances Added to Food inventory under CAS 18383-49-8.
Structure
Identity
Also known as: 7-Oxabicyclo[4.1.0]heptan-2-one, 1-methyl-4-(1-methylethenyl)-, (1S,4R,6S)-, p-Menth-8-en-2-one, 1,6-epoxy-, (1S,4R,6S)-, 7-Oxabicyclo[4.1.0]heptan-2-one, 1-methyl-4-(1-methylethenyl)-, [1S-(1α,4β,6α)]-, (1S,4R,6S)-1-Methyl-4-(1-methylethenyl)-7-oxabicyclo[4.1.0]heptan-2-one, trans-Carvone oxide, L-(-)-Carvone cis-epoxide, carvone-5,6-oxide, cis-(-)-, (1s,4r,6s)-1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptan-2-one, cis-carvone oxide, carvone oxide, cis-, (1s,4r,6s)-1-methyl-4-prop-1-en-2-yl-7-oxabicyclo[4.1.0]heptan-2-one, 1,6-epoxy-p-menth-8-en-2-one, (1s,4r,6s)-.
Can trans-Carvone-5,6-oxide be labeled natural?
trans-Carvone-5,6-oxide occurs in nature, so the label depends on the route: trans-Carvone-5,6-oxide won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized trans-Carvone-5,6-oxide is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
trans-Carvone-5,6-oxide is FEMA GRAS under FEMA number 4084. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for trans-Carvone-5,6-oxide. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 1572, evaluated at the 65th meeting in 2005. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, minty, herbal, green, fresh.
Where it is used
trans-Carvone-5,6-oxide is used in beverage, confection, flavoring and cosmetics, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to trans-Carvone-5,6-oxide by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| l-8-p-Menthene-1,2-epoxide | 4656 | 93% | In nature |
| Piperitenone oxide | 4199 | 84% | In nature |
| beta-Ionone epoxide | 4144 | 74% | In nature |
| Ethyl methyl-p-tolylglycidate | 3757 | 62% | In nature |
| Epoxy oxophorone | 4109 | 60% | In nature |
More terpenes in this index
4-Methylidene-2-(2-methylprop-1-enyl)oxane · Cubebol · Allyl alpha-ionone · Myrtenol · Farnesene · 3,7-Dimethyl-1,3,6-octatriene
trans-Carvone-5,6-oxide FAQ
Does trans-Carvone-5,6-oxide have FEMA GRAS status?
trans-Carvone-5,6-oxide holds FEMA GRAS status under FEMA number 4084. It is also codified at 21 CFR 172.515.
How do I cite trans-Carvone-5,6-oxide by FEMA or CAS number?
Cite trans-Carvone-5,6-oxide as FEMA 4084 or CAS 18383-49-8; both point to the same entry. FEMA files it in the fruity flavor category.
Can trans-Carvone-5,6-oxide be labeled a natural flavor?
Since trans-Carvone-5,6-oxide is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when trans-Carvone-5,6-oxide is synthesized. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
Is trans-Carvone-5,6-oxide approved in the EU?
No EU FL number is on file for trans-Carvone-5,6-oxide. It has a JECFA evaluation (JECFA 1572), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated trans-Carvone-5,6-oxide?
Yes. JECFA number 1572, evaluated at the 65th meeting in 2005. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What does trans-Carvone-5,6-oxide smell and taste like, and where is it used?
The odor of trans-Carvone-5,6-oxide is sweet, minty, herbal, green, fresh. Typical uses are beverage, confection, flavoring and cosmetics.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as CIS-CARVONE OXIDE under CAS 18383-49-8 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.