Flavor ingredient regulatory record
2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine
2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine is a thiol in the earthy family, FEMA GRAS under FEMA number 4017 (CAS 74595-94-1). Its odor is earthy, sulfurous, musty, pungent.
- FEMA
- 4017
- CAS
- 74595-94-1
- JECFA
- 1048
- EU FL
- 15.113
- Formula
- C15H31NS2
- EC
- 457-290-0
GRAS status: FEMA GRAS, publication 20. Recorded by FDA in the Substances Added to Food inventory under CAS 74595-94-1.
Structure
Identity
Also known as: 4H-1,3,5-Dithiazine, dihydro-2,4,6-tris(2-methylpropyl)-, Dihydro-2,4,6-tris(2-methylpropyl)-4H-1,3,5-dithiazine, dihydro-2,4,6-tris(2-methylpropyl)-4h-1,3,5-dithiazine, 2,4,6-tris(2-methylpropyl)-1,3,5-dithiazinane, 2,4,6-triisobutyl-1,3,5-dithiazinane, 2,4,6-triisobutyl-5,6-dihydro-4h-1,3,5-dithiazine [fhfi], 4h-1,3,5-dithiazine, dihydro-2,4,6-tris(2-methylpropyl)-, bacon dithiazine, 2,4,6-tri-(2-methylpropyl) tetrahydro-1,3,5-dithiazine.
Can 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine is FEMA GRAS under FEMA number 4017. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 15.113, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1048.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Earthy, sulfurous, musty, pungent.
Where it is used
2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine is used in savory dishes, seasonings, sauces and snacks, typically as a earthy note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Isobutyl-4,6-dimethyldihydro-1,3,5-dithiazine and 4-isobutyl-2,6-dimethyldihydro-1,3,5-dithiazine | 3781 | 68% | In nature |
| WS-3 | 3455 | 61% | In nature |
| N-(2-(Pyridin-2-yl)ethyl)-3-p-menthanecarboxamide | 4549 | 60% | Not determined |
| Menthyl valerate | 4156 | 59% | In nature |
| Butanal dibenzyl thioacetal | 4589 | 59% | Not determined |
More thiols in this index
Benzothiazole · Pyrrolidino-[1,2e]-4H-2,4-dimethyl-1,3,5-dithiazine · 2-Pentylthiophene · 5,7-Dihydro-2-methylthieno(3,4-d)pyrimidine · Methyl 3-methyl-1-butenyl disulfide · 2-Pentenyl-4-propyl-1,3-oxathiane
2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine FAQ
Is 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine FEMA GRAS?
Yes. The FEMA Expert Panel lists 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine as GRAS under FEMA number 4017. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine?
2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine is FEMA 4017, CAS 74595-94-1. Its flavor category is earthy.
How is 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine described, and where does it show up?
Flavorists describe 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine as earthy, sulfurous, musty, pungent. It is used in savory dishes, seasonings, sauces and snacks.
What did JECFA conclude about 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine?
JECFA evaluated 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine under JECFA number 1048.
Is 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine on the EU Union List?
Yes. FL 15.113 is the Union List entry for 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as DIHYDRO-2,4,6-TRIS(2-METHYLPROPYL)-4H-1,3,5-DITHIAZINE under CAS 74595-94-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.