Flavor ingredient regulatory record
Menthyl valerate
Menthyl valerate is an ester in the fruity family, FEMA GRAS under FEMA number 4156 (CAS 89-47-4). Its odor is sweet, fruity, minty, floral, estery.
- FEMA
- 4156
- CAS
- 89-47-4
- JECFA
- 1852
- EU FL
- 09.154
- Formula
- C15H28O2
- EC
- 201-910-2
GRAS status: FEMA GRAS, publication 22. Recorded by FDA in the Substances Added to Food inventory under CAS 89-47-4.
Structure
Identity
Also known as: Butanoic acid, 3-methyl-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, rel-, Menthol, isovalerate, Butanoic acid, 3-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1α,2β,5α)-, Isovaleric acid menthyl ester, p-Menth-3-yl isovalerate, dl-Menthyl isovalerate, l-menthyl isovalerate, menthyl isovalerate, (-)-, butanoic acid, 3-methyl-, (1r,2s,5r)-5-methyl-2-(1-methylethyl)cyclohexyl ester, dl-menthyl isovalerate, menthyl isovalerate [mi], menthyl isovalerate [fhfi].
Can Menthyl valerate be labeled natural?
Menthyl valerate occurs in nature, so the label depends on the route: menthyl valerate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized menthyl valerate is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Menthyl valerate is FEMA GRAS under FEMA number 4156. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.154, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1852, evaluated at the 69th meeting in 2008. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Menthyl valerate appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 89-47-4, where EPA names it Butanoic acid, 3-methyl-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, rel-.
Inactive in US commerce
EPA designates this substance inactive, so a Notice of Activity Form B is required before anyone manufactures or processes it again. Being FEMA GRAS does not change that. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, minty, floral, estery.
Where it is used
Menthyl valerate is used in beverage, confection, fruit flavors, ice cream and candies, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Menthyl valerate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| l-Menthyl butyrate | 4524 | 95% | Not determined |
| Menthyl isovalerate | 2669 | 91% | In nature |
| Menthyl propionate | 4510 | 86% | Not determined |
| l-Menthyl acetoacetate | 4327 | 85% | In nature |
| (-)-Menthol 1- and 2-propylene glycol carbonate | 3806 | 80% | Not determined |
More esters in this index
Ethyl 3-octenoate · (E)-Ethyl 3-(2-furyl)acrylate · Isobutyl N-methylanthranilate · Isoamyl acetate · Ethyl 3-hydroxybutyrate · (E,Z)-3,6-Nonadien-1-ol acetate
Menthyl valerate FAQ
Does menthyl valerate have FEMA GRAS status?
Menthyl valerate holds FEMA GRAS status under FEMA number 4156. It is also codified at 21 CFR 172.515.
How do I cite menthyl valerate by FEMA or CAS number?
Cite menthyl valerate as FEMA 4156 or CAS 89-47-4; both point to the same entry. FEMA files it in the fruity flavor category.
Can menthyl valerate be labeled a natural flavor?
Since menthyl valerate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when menthyl valerate is synthesized. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
Can menthyl valerate be used in the EU and UK?
Menthyl valerate is on the EU Union List of flavouring substances as FL 09.154 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated menthyl valerate?
Yes. JECFA number 1852, evaluated at the 69th meeting in 2008. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What does menthyl valerate smell and taste like, and where is it used?
The odor of menthyl valerate is sweet, fruity, minty, floral, estery. Typical uses are beverage, confection, fruit flavors, ice cream and candies.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as MENTHYL VALERATE under CAS 89-47-4 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.