Flavor ingredient regulatory record
2-Acetoxy-3-butanone
2-Acetoxy-3-butanone is an ester in the fruity family, FEMA GRAS under FEMA number 3526 (CAS 4906-24-5). Its odor is sweet, fruity, apple, caramel, estery.
- FEMA
- 3526
- CAS
- 4906-24-5
- JECFA
- 406
- EU FL
- 09.186
- Formula
- C6H10O3
GRAS status: FEMA GRAS, publication 11. Recorded by FDA in the Substances Added to Food inventory under CAS 4906-24-5.
Structure
Identity
Also known as: 2-Butanone, 3-(acetyloxy)-, 2-Butanone, 3-hydroxy-, acetate, 3-(Acetyloxy)-2-butanone, 3-Acetoxy-2-butanone, Acetoin acetate, 3-Acetyloxy-2-butanone, Acetic acid 1-methyl-2-oxopropyl ester, 3-Oxobutan-2-yl acetate, acetoin acetate, 3-acetoxy-2-butanone, 2-butanone, 3-(acetyloxy)-, 3-(acetyloxy)-2-butanone.
Can 2-Acetoxy-3-butanone be labeled natural?
Since 2-Acetoxy-3-butanone is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when 2-Acetoxy-3-butanone is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 2-Acetoxy-3-butanone identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2-Acetoxy-3-butanone is FEMA GRAS under FEMA number 3526. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.186, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 406, evaluated at the 51st meeting in 1998. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, apple, caramel, estery.
Where it is used
2-Acetoxy-3-butanone is used in beverage, confection, fruit flavors, bakery and desserts, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Acetoxy-3-butanone by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Propyl acetate | 2925 | 88% | In nature |
| 2,3-Hexanedione | 2558 | 86% | In nature |
| 3-Oxobutanal dimethyl acetal | 3381 | 78% | In nature |
| Methyl thiobutyrate | 3310 | 78% | In nature |
| 2-Methyl-5-(methylthio)furan | 3366 | 76% | In nature |
More esters in this index
alpha-Terpinyl acetate · 2-Phenoxyethyl propionate · Butyl anthranilate · Ethyl butyrate · Cinnamyl formate · Butyl salicylate
2-Acetoxy-3-butanone FAQ
Does 2-Acetoxy-3-butanone have FEMA GRAS status?
2-Acetoxy-3-butanone holds FEMA GRAS status under FEMA number 3526. It is also codified at 21 CFR 172.515.
How do I cite 2-Acetoxy-3-butanone by FEMA or CAS number?
Cite 2-Acetoxy-3-butanone as FEMA 3526 or CAS 4906-24-5; both point to the same entry. FEMA files it in the fruity flavor category.
Can 2-Acetoxy-3-butanone be labeled a natural flavor?
2-Acetoxy-3-butanone occurs in nature, so the label depends on the route: 2-Acetoxy-3-butanone won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized 2-Acetoxy-3-butanone is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Can 2-Acetoxy-3-butanone be used in the EU and UK?
2-Acetoxy-3-butanone is on the EU Union List of flavouring substances as FL 09.186 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated 2-Acetoxy-3-butanone?
Yes. JECFA number 406, evaluated at the 51st meeting in 1998. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What does 2-Acetoxy-3-butanone smell and taste like, and where is it used?
The odor of 2-Acetoxy-3-butanone is sweet, fruity, apple, caramel, estery. Typical uses are beverage, confection, fruit flavors, bakery and desserts.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ACETYL METHYL CARBINYL ACETATE under CAS 4906-24-5 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.