Flavor ingredient regulatory record
2-Ethoxy-3-ethylpyrazine
2-Ethoxy-3-ethylpyrazine is a pyrazine in the fruity family, FEMA GRAS under FEMA number 4633 (CAS 35243-43-7). Its odor is nutty, roasted, earthy, sweet, green.
- FEMA
- 4633
- CAS
- 35243-43-7
- JECFA
- 2131
- Formula
- C8H12N2O
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 35243-43-7.
Structure
Identity
Also known as: 3-ethyl-2-ethoxypyrazine, pyrazine, 2-ethoxy-3-ethyl-, pyrazine, 2-ethoxy-3-ethyl, pyrazine, 3-ethoxy-2-ethyl, 2-ethoxy- 3-ethylpyrazine, 2-ethoxy-3-ethyl-pyrazine, db-021012, cs-0359209, e0812.
Can 2-Ethoxy-3-ethylpyrazine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2-Ethoxy-3-ethylpyrazine is FEMA GRAS under FEMA number 4633. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 2-Ethoxy-3-ethylpyrazine. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2131.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Nutty, roasted, earthy, sweet, green.
Taste: Savory, nutty, earthy.
Where it is used
2-Ethoxy-3-ethylpyrazine is used in beverage, snacks, savory dishes and seasonings, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Ethoxy-3-ethylpyrazine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Ethoxy-3-methylpyrazine | 3569 | 94% | In nature |
| 2-Ethoxy-3-isopropylpyrazine | 4632 | 93% | Not determined |
| 2-Methoxy-3-(1-methylpropyl)pyrazine | 3433 | 89% | In nature |
| 2,3-Diethyl-5-methylpyrazine | 3336 | 88% | In nature |
| 2-Isopropyl-3-methoxypyrazine | 3358 | 79% | In nature |
More pyrazines in this index
1-Pyrroline · 2-Ethoxy-3-isopropylpyrazine · 2-Ethoxy-3-methylpyrazine · Cyclohexylmethylpyrazine · 6,7-Dihydro-2,3-dimethyl-5H-cyclopentapyrazine · 2-Acetyl-1-pyrroline
2-Ethoxy-3-ethylpyrazine FAQ
Does 2-Ethoxy-3-ethylpyrazine have FEMA GRAS status?
2-Ethoxy-3-ethylpyrazine holds FEMA GRAS status under FEMA number 4633. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite 2-Ethoxy-3-ethylpyrazine by FEMA or CAS number?
Cite 2-Ethoxy-3-ethylpyrazine as FEMA 4633 or CAS 35243-43-7; both point to the same entry. Its flavor category is fruity.
What does 2-Ethoxy-3-ethylpyrazine smell and taste like, and where is it used?
The odor of 2-Ethoxy-3-ethylpyrazine is nutty, roasted, earthy, sweet, green. On the palate it is savory, nutty, earthy. Typical uses are beverage, snacks, savory dishes and seasonings.
What did JECFA conclude about 2-Ethoxy-3-ethylpyrazine?
JECFA evaluated 2-Ethoxy-3-ethylpyrazine under JECFA number 2131.
Is 2-Ethoxy-3-ethylpyrazine approved in the EU?
No EU FL number is on file for 2-Ethoxy-3-ethylpyrazine. It has a JECFA evaluation (JECFA 2131), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-ETHOXY-3-ETHYLPYRAZINE under CAS 35243-43-7 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.