Flavor ingredient regulatory record
2-Isobutylpyridine
2-Isobutylpyridine is a pyridine in the spice family, FEMA GRAS under FEMA number 3370 (CAS 6304-24-1). Its odor is earthy, spicy, woody, herbal.
- FEMA
- 3370
- CAS
- 6304-24-1
- JECFA
- 1311
- EU FL
- 14.058
- Formula
- C9H13N
- EC
- 228-606-2
GRAS status: FEMA GRAS, publication 6. Recorded by FDA in the Substances Added to Food inventory under CAS 6304-24-1.
Structure
Identity
Also known as: Pyridine, 2-(2-methylpropyl)-, Pyridine, 2-isobutyl-, 2-(2-Methylpropyl)pyridine, NSC 42623, 2-(2-Methylprop-1-yl)pyridine, 2-(2-methylpropyl)pyridine, 2-isobutyl pyridine, pyridine, 2-(2-methylpropyl)-, 2-(2-methylpropyl)pyridine [fhfi], pyridine, 2-isobutyl-, 2-isobutyl-pyridin, 2-isobutyl-pyridine.
Can 2-Isobutylpyridine be labeled natural?
Since 2-Isobutylpyridine is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when 2-Isobutylpyridine is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 2-Isobutylpyridine identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2-Isobutylpyridine is FEMA GRAS under FEMA number 3370. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 14.058, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1311, evaluated at the 69th meeting in 2008. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Earthy, spicy, woody, herbal.
Where it is used
2-Isobutylpyridine is used in savory dishes, seasonings, snacks and beverages, typically as a spice note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Isobutylpyridine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Propylpyridine | 4065 | 90% | In nature |
| 3-Isobutylpyridine | 3371 | 86% | In nature |
| 5-Ethyl-2-methylpyridine | 3546 | 74% | In nature |
| 3-Ethylpyridine | 3394 | 63% | In nature |
| 2-Isobutyl-3-methoxypyrazine | 3132 | 62% | In nature |
More pyridines in this index
3-Ethylpyridine · 2,4-Dimethylpyridine · 2-Propylpyridine · 2,6-Dimethylpyridine · 2-Methoxypyridine · 2-Acetyl-4-isopropenylpyridine
2-Isobutylpyridine FAQ
Does 2-Isobutylpyridine have FEMA GRAS status?
2-Isobutylpyridine holds FEMA GRAS status under FEMA number 3370. It is also codified at 21 CFR 172.515.
How do I cite 2-Isobutylpyridine by FEMA or CAS number?
Cite 2-Isobutylpyridine as FEMA 3370 or CAS 6304-24-1; both point to the same entry. FEMA files it in the spice flavor category.
Can 2-Isobutylpyridine be labeled a natural flavor?
2-Isobutylpyridine occurs in nature, so the label depends on the route: 2-Isobutylpyridine won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized 2-Isobutylpyridine is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Can 2-Isobutylpyridine be used in the EU and UK?
2-Isobutylpyridine is on the EU Union List of flavouring substances as FL 14.058 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated 2-Isobutylpyridine?
Yes. JECFA number 1311, evaluated at the 69th meeting in 2008. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What does 2-Isobutylpyridine smell and taste like, and where is it used?
The odor of 2-Isobutylpyridine is earthy, spicy, woody, herbal. Typical uses are savory dishes, seasonings, snacks and beverages.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-(2-METHYLPROPYL)PYRIDINE under CAS 6304-24-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.