Flavor ingredient regulatory record
2-Methoxypyridine
2-Methoxypyridine is a pyridine in the earthy family, FEMA GRAS under FEMA number 4639 (CAS 1628-89-3). Its odor is earthy, herbal, musty, woody.
- FEMA
- 4639
- CAS
- 1628-89-3
- JECFA
- 2156
- Formula
- C6H7NO
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 1628-89-3.
Structure
Identity
Also known as: Pyridine, 2-methoxy-, pyridine, 2-methoxy-, ai3-62040, pyridine, 2methoxy, pyridine, methoxy-, 2-methoxy-pyridine, methoxypyridine, 6-methoxypyridine, methyl pyridinyl ether, 2-methoxypyridine, 98%, cs-w009307, ebc-656492.
Can 2-Methoxypyridine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2-Methoxypyridine is FEMA GRAS under FEMA number 4639. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for 2-Methoxypyridine. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2156, evaluated at the 76th meeting in 2012. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Earthy, herbal, musty, woody.
Where it is used
2-Methoxypyridine is used in savory dishes, seasoning blends, snack foods and beverages, typically as a earthy note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Methoxypyridine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Methoxypyrazine | 3302 | 92% | In nature |
| Anisole | 2097 | 92% | In nature |
| 1-Methoxy-2-methylbenzene | 2680 | 90% | In nature |
| 3-Ethylpyridine | 3394 | 85% | In nature |
| 2-Acetylpyridine | 3251 | 85% | In nature |
More pyridines in this index
2-Pentylpyridine · 3-Isobutylpyridine · 2-Propylpyridine · 2-Hexylpyridine · 2-Isobutylpyridine · 2,4-Dimethylpyridine
2-Methoxypyridine FAQ
Does 2-Methoxypyridine have FEMA GRAS status?
2-Methoxypyridine holds FEMA GRAS status under FEMA number 4639. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite 2-Methoxypyridine by FEMA or CAS number?
Cite 2-Methoxypyridine as FEMA 4639 or CAS 1628-89-3; both point to the same entry. Its flavor category is earthy.
What does 2-Methoxypyridine smell and taste like, and where is it used?
The odor of 2-Methoxypyridine is earthy, herbal, musty, woody. Typical uses are savory dishes, seasoning blends, snack foods and beverages.
What did JECFA conclude about 2-Methoxypyridine?
JECFA evaluated 2-Methoxypyridine at the 76th meeting in 2012 under JECFA number 2156. The panel concluded: no safety concern at current levels of intake.
Is 2-Methoxypyridine approved in the EU?
No EU FL number is on file for 2-Methoxypyridine. It has a JECFA evaluation (JECFA 2156), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Check 2-Methoxypyridine in a formula
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-METHOXYPYRIDINE under CAS 1628-89-3 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.