Flavor ingredient regulatory record
2-Thienyl disulfide
2-Thienyl disulfide is a thiol in the sulfur family, FEMA GRAS under FEMA number 3323 (CAS 6911-51-9). Its odor is garlic, onion, pungent, earthy, sulfurous.
- FEMA
- 3323
- CAS
- 6911-51-9
- JECFA
- 1053
- EU FL
- 15.008
- Formula
- C8H6S4
GRAS status: FEMA GRAS, publication 5. Recorded by FDA in the Substances Added to Food inventory under CAS 6911-51-9.
Structure
Identity
Also known as: Thiophene, 2,2′-dithiobis-, Thiophene, 2,2′-dithiodi-, 2,2′-Dithiobis[thiophene], α,α′-Dithienyl disulfide, 2,2′-Bis(thienyl) disulfide, Di-2-thienyl disulfide, Bis(2-thienyl) disulfide, 1,2-Di(thien-2-yl)disulfane, 2,2′-Dithiodithiophene, 2-(Thiophen-2-yldisulfanyl)thiophene.
Can 2-Thienyl disulfide be labeled natural?
The process decides for 2-Thienyl disulfide. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic 2-Thienyl disulfide is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 2-Thienyl disulfide identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2-Thienyl disulfide is FEMA GRAS under FEMA number 3323. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 15.008, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1053, evaluated at the 59th meeting in 2002. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Garlic, onion, pungent, earthy, sulfurous.
Where it is used
2-Thienyl disulfide is used in savory dishes, seasoning blends, condiments and snacks, typically as a sulfur note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Thienyl disulfide by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Phenyl disulfide | 3225 | 68% | In nature |
| bis-(2-Methyl-3-furyl) tetrasulfide | 3260 | 64% | In nature |
| bis-(2-Methyl-3-furyl) disulfide | 3259 | 63% | In nature |
| 2,2'-(Dithiodimethylene)difuran | 3146 | 57% | In nature |
More thiols in this index
2-Mercaptoanisole · 2-Ethylthiophenol · 2-Methylthiophene · 4-Mercapto-4-methyl-2-hexanone · Benzenethiol · Methyl 3-methyl-1-butenyl disulfide
2-Thienyl disulfide FAQ
Is 2-Thienyl disulfide on the FEMA GRAS list?
It is. FEMA number 3323 covers 2-Thienyl disulfide. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for 2-Thienyl disulfide?
The FEMA number for 2-Thienyl disulfide is 3323 and its CAS registry number is 6911-51-9. Its flavor category is sulfur.
What is 2-Thienyl disulfide used for?
2-Thienyl disulfide is described as garlic, onion, pungent, earthy, sulfurous. It shows up in savory dishes, seasoning blends, condiments and snacks.
What did JECFA conclude about 2-Thienyl disulfide?
JECFA evaluated 2-Thienyl disulfide at the 59th meeting in 2002 under JECFA number 1053. The panel concluded: no safety concern at current levels of intake.
Is 2-Thienyl disulfide approved in the EU?
Yes. FL 15.008 is the Union List entry for 2-Thienyl disulfide, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Is 2-Thienyl disulfide natural or artificial?
Nature makes 2-Thienyl disulfide, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial 2-Thienyl disulfide, same molecule. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Ingredient lookup
Check an ingredient
Start typing to search the ingredient corpus.
Or browse every ingredient page, A to Z.
Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
Check 2-Thienyl disulfide in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-THIENYL DISULFIDE under CAS 6911-51-9 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.