Flavor ingredient regulatory record
4-Methyl-2,3-pentanedione
4-Methyl-2,3-pentanedione is a ketone in the fruity family, FEMA GRAS under FEMA number 2730 (CAS 7493-58-5). Its odor is sweet, creamy, buttery, caramel, fruity.
- FEMA
- 2730
- CAS
- 7493-58-5
- JECFA
- 411
- EU FL
- 07.063
- Formula
- C6H10O2
- EC
- 231-328-4
GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 7493-58-5.
Structure
Identity
Also known as: 2,3-Pentanedione, 4-methyl-, Acetyl isobutyryl, NSC 31666, acetyl isobutyryl, 4-methylpentane-2,3-dione, 2,3-pentanedione, 4-methyl-, acetylisobutyryl, isopropylmethylglyoxal, 4-methyl-2,3-pentanedione [fhfi], 4methyl2,3pentanedione, 2,3pentanedione, 4methyl, isopropyl methyl diketone.
Can 4-Methyl-2,3-pentanedione be labeled natural?
Since 4-Methyl-2,3-pentanedione is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when 4-Methyl-2,3-pentanedione is synthesized. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
4-Methyl-2,3-pentanedione is FEMA GRAS under FEMA number 2730. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 07.063, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 411, evaluated at the 51st meeting in 1998. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list. Listed on the EPA TSCA inventory.
Odor and taste
Odor: Sweet, creamy, buttery, caramel, fruity.
Where it is used
4-Methyl-2,3-pentanedione is used in beverage, confection, dairy, bakery and flavoring, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 4-Methyl-2,3-pentanedione by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2,3-Pentadione | 2841 | 91% | In nature |
| Methyl isobutanethioate | 4586 | 88% | Not determined |
| 4-Methyl-2-pentanone | 2731 | 87% | In nature |
| 2-Pentanone | 2842 | 80% | In nature |
| 3,4-Hexanedione | 3168 | 77% | In nature |
More ketones in this index
2-Methylacetophenone · 3-Methyl-1-cyclopentadecanone · 3-Methylcyclohexanone · Dihydro-alpha-ionone · (+/-)-3-Hydroxy-3-methyl-2,4-nonanedione · 3-Octen-2-one
4-Methyl-2,3-pentanedione FAQ
Is 4-Methyl-2,3-pentanedione FEMA GRAS?
Yes. The FEMA Expert Panel lists 4-Methyl-2,3-pentanedione as GRAS under FEMA number 2730. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for 4-Methyl-2,3-pentanedione?
4-Methyl-2,3-pentanedione is FEMA 2730, CAS 7493-58-5. FEMA files it in the fruity flavor category.
Does 4-Methyl-2,3-pentanedione count as natural in the US and the EU?
4-Methyl-2,3-pentanedione occurs in nature, so the label depends on the route: 4-Methyl-2,3-pentanedione won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized 4-Methyl-2,3-pentanedione is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 4-Methyl-2,3-pentanedione identical-to-natural.
Is 4-Methyl-2,3-pentanedione on the EU Union List?
4-Methyl-2,3-pentanedione is on the EU Union List of flavouring substances as FL 07.063 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated 4-Methyl-2,3-pentanedione?
Yes. JECFA number 411, evaluated at the 51st meeting in 1998. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
How is 4-Methyl-2,3-pentanedione described, and where does it show up?
Flavorists describe 4-Methyl-2,3-pentanedione as sweet, creamy, buttery, caramel, fruity. It is used in beverage, confection, dairy, bakery and flavoring.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 4-METHYL-2,3-PENTANEDIONE under CAS 7493-58-5 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.