Flavor ingredient regulatory record
Advantame
Advantame is an amide in the sweet family, FEMA GRAS under FEMA number 4716 (CAS 714229-20-6). Its odor is sweet, creamy, vanilla, slightly fruity.
- FEMA
- 4716
- CAS
- 714229-20-6
- Formula
- C24H32N2O8
GRAS status: FEMA GRAS, publication 25. Recorded by FDA in the Substances Added to Food inventory under CAS 714229-20-6.
Structure
Identity
Also known as: advantame monohydrate, l-phenylalanine, n-(3-(3-hydroxy-4-methoxyphenyl)propyl)-l-alpha-aspartyl-, 2-methyl ester, hydrate (1:1), l-phenylalanine, n-(3-(3-hydroxy-4-methoxyphenyl)propyl)-l-alpha-aspartyl-, 2-methyl ester, monohydrate, phenylalanine, n-(3-(3-hydroxy-4-methoxyphenyl)propyl)-alpha-aspartyl-, 2-methyl ester, monohydrate, advantame hydrate, advantame [usp-rs], ins no.969, ins-969, ex-a8009, hy-122351a, da-50248, e969.
Can Advantame be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Advantame is FEMA GRAS under FEMA number 4716. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Advantame. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
Advantame has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, creamy, vanilla, slightly fruity.
Taste: Sweet, umami, mild.
Where it is used
Advantame is used in beverage, confection, baked goods, dairy and flavoring agent, typically as a sweet note.
More amides in this index
N-Ethyl-2,2-diisopropylbutanamide · (2S,5R)-N-[4-(2-Amino-2-oxoethyl)phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide · N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(5-methylpyridin-2-yl)ethyl)oxalamide · N-p-Benzene acetonitrile-menthane-carboxamide · 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide · N-(2-(Pyridin-2-yl)ethyl)-3-p-menthanecarboxamide
Advantame FAQ
Is advantame FEMA GRAS?
Yes. The FEMA Expert Panel lists advantame as GRAS under FEMA number 4716. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for advantame?
Advantame is FEMA 4716, CAS 714229-20-6. FEMA files it in the sweet flavor category.
How is advantame described, and where does it show up?
Flavorists describe advantame as sweet, creamy, vanilla, slightly fruity. On the palate it is sweet, umami, mild. It is used in beverage, confection, baked goods, dairy and flavoring agent.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ADVANTAME under CAS 714229-20-6 and carries its FEMA number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as non-nutritive sweetener.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.