Flavor ingredient regulatory record
Diisoamyl disulfide
Diisoamyl disulfide is a thiol in the sulfur family, FEMA GRAS under FEMA number 4575 (CAS 2051-04-9). Its odor is garlic, onion, pungent, earthy.
- FEMA
- 4575
- CAS
- 2051-04-9
- JECFA
- 1930
- Formula
- C10H22S2
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 2051-04-9.
Structure
Identity
Also known as: Disulfide, bis(3-methylbutyl), Isopentyl disulfide, Bis(3-methylbutyl) disulfide, Isoamyl disulfide, 2,9-Dimethyl-5,6-dithiadecane, Diisopentyl disulfide, NSC 677439, NSC 2362, 3-Methyl-1-(3-methylbutyldisulfanyl)butane, isoamyl disulfide, bis(3-methylbutyl) disulfide, disulfide, bis(3-methylbutyl).
Can Diisoamyl disulfide be labeled natural?
The process decides for diisoamyl disulfide. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic diisoamyl disulfide is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Diisoamyl disulfide is FEMA GRAS under FEMA number 4575. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Diisoamyl disulfide. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 1930.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Garlic, onion, pungent, earthy.
Where it is used
Diisoamyl disulfide is used in savory dishes, seasoning, sauces and snacks, typically as a sulfur note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Diisoamyl disulfide by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2,4,6-Triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine | 4017 | 56% | Not determined |
More thiols in this index
4-Mercapto-4-methyl-2-hexanone · Dimercaptomethane · 2,3 or 10-Mercaptopinane · 3-Methylbutanethiol · DL-Methionine · 2,6-(Dimethyl)thiophenol
Diisoamyl disulfide FAQ
Is diisoamyl disulfide FEMA GRAS?
Yes. The FEMA Expert Panel lists diisoamyl disulfide as GRAS under FEMA number 4575. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for diisoamyl disulfide?
Diisoamyl disulfide is FEMA 4575, CAS 2051-04-9. Its flavor category is sulfur.
How is diisoamyl disulfide described, and where does it show up?
Flavorists describe diisoamyl disulfide as garlic, onion, pungent, earthy. It is used in savory dishes, seasoning, sauces and snacks.
What did JECFA conclude about diisoamyl disulfide?
JECFA evaluated diisoamyl disulfide under JECFA number 1930.
Is diisoamyl disulfide approved in the EU?
No EU FL number is on file for diisoamyl disulfide. It has a JECFA evaluation (JECFA 1930), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Does diisoamyl disulfide count as natural in the US and the EU?
Nature makes diisoamyl disulfide, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial diisoamyl disulfide, same molecule. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
Ingredient lookup
Check an ingredient
Start typing to search the ingredient corpus.
Or browse every ingredient page, A to Z.
Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
Check Diisoamyl disulfide in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as DIISOAMYL DISULFIDE under CAS 2051-04-9 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.