Flavor ingredient regulatory record
DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride
DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride is a quaternary ammonium compound in the savory family, FEMA GRAS under FEMA number 3445 (CAS 1115-84-0). Its odor is umami, savory, broth, meaty.
- FEMA
- 3445
- CAS
- 1115-84-0
- JECFA
- 1427
- Formula
- C6H14ClNO2S
- EC
- 214-231-1
GRAS status: FEMA GRAS, publication 9. Recorded by FDA in the Substances Added to Food inventory under CAS 3493-12-7.
Structure
Identity
Also known as: Sulfonium, [(3S)-3-amino-3-carboxypropyl]dimethyl-, chloride (1:1), Sulfonium, (3-amino-3-carboxypropyl)dimethyl-, chloride, L-, Sulfonium, (3-amino-3-carboxypropyl)dimethyl-, chloride, (S)-, Vitamin U, Sulfonium, [(3S)-3-amino-3-carboxypropyl]dimethyl-, chloride, Methylmethioninesulfonium chloride, L-Methylmethionine sulfonium chloride, Cabagin, S-Methylmethionine sulfonium chloride, L-Methionine methylsulfonium chloride, S-Methylmethionine chloride, Ardesyl.
Can DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride be labeled natural?
Nature makes DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride, same molecule. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride is FEMA GRAS under FEMA number 3445. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 1427, evaluated at the 64th meeting in 2005. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Umami, savory, broth, meaty.
Taste: Savory, salty, umami.
Where it is used
DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride is used in seasoning, sauces, snacks and meat products, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| DL-Methionine | 3301 | 76% | In nature |
| L-Glutamine | 3684 | 57% | In nature |
| L-Methionylglycine | 4692 | 53% | Not determined |
| Leucine | 3297 | 53% | In nature |
| l-Glutamic acid | 3285 | 52% | In nature |
More quaternary ammonium compounds in this index
DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride FAQ
Does DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride have FEMA GRAS status?
DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride holds FEMA GRAS status under FEMA number 3445. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride by FEMA or CAS number?
Cite DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride as FEMA 3445 or CAS 1115-84-0; both point to the same entry. Its flavor category is savory.
What does DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride smell and taste like, and where is it used?
The odor of DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride is umami, savory, broth, meaty. On the palate it is savory, salty, umami. Typical uses are seasoning, sauces, snacks and meat products.
What did JECFA conclude about DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride?
JECFA evaluated DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride at the 64th meeting in 2005 under JECFA number 1427. The panel concluded: no safety concern at current levels of intake.
Is DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride approved in the EU?
No EU FL number is on file for DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride. It has a JECFA evaluation (JECFA 1427), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Can DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride be labeled a natural flavor?
The process decides for DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic DL-(3-Amino-3-carboxypropyl)dimethylsufonium chloride is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE under CAS 3493-12-7 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.