Flavor ingredient regulatory record
L-Methionylglycine
L-Methionylglycine is an amino acid in the savory family, FEMA GRAS under FEMA number 4692 (CAS 14486-03-4). Its odor is umami, savory, meaty, broth.
- FEMA
- 4692
- CAS
- 14486-03-4
- JECFA
- 2122
- EU FL
- 17.037
- Formula
- C7H14N2O3S
- EC
- 238-487-9
GRAS status: FEMA GRAS, publication 25. Recorded by FDA in the Substances Added to Food inventory under CAS 14486-03-4.
Structure
Identity
Also known as: Glycine, L-methionyl-, Glycine, N-L-methionyl-, NSC 88865, 317: PN: WO2008077945 SEQID: 323 claimed protein, 205: PN: WO2008142164 SEQID: 206 claimed protein, 38: PN: US20100104568 SEQID: 206 claimed protein, 218: PN: WO2010066835 SEQID: 262 unclaimed sequence, 61: PN: WO2010070145 SEQID: 219 unclaimed sequence, 34: PN: FR2949473 SEQID: 18 unclaimed protein, 21: PN: WO2011023914 SEQID: 18 unclaimed protein, 5: PN: WO2017095140 PAGE: 4 claimed sequence, 16: PN: WO2018144831 SEQID: 16 claimed protein.
Can L-Methionylglycine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
L-Methionylglycine is FEMA GRAS under FEMA number 4692. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 17.037, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 2122.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Umami, savory, meaty, broth.
Where it is used
L-Methionylglycine is used in seasoning, sauces, snacks and meat products, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to L-Methionylglycine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| L-Alanyl-L-Glutamine | 4712 | 79% | Not determined |
| Glutamyl-valyl-glycine | 4709 | 67% | Not determined |
| L-Glutamine | 3684 | 66% | In nature |
| DL-Methionine | 3301 | 65% | In nature |
| N-Lactoyl ethanolamine | 4256 | 64% | Not determined |
More amino acids in this index
Leucine · L-Ornithine monochlorohydrate · L-Isoleucine · L-Glutamine · L-Alanine · L-Threonine
L-Methionylglycine FAQ
Is L-Methionylglycine FEMA GRAS?
Yes. The FEMA Expert Panel lists L-Methionylglycine as GRAS under FEMA number 4692. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for L-Methionylglycine?
L-Methionylglycine is FEMA 4692, CAS 14486-03-4. FEMA files it in the savory flavor category.
Is L-Methionylglycine on the EU Union List?
L-Methionylglycine is on the EU Union List of flavouring substances as FL 17.037 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated L-Methionylglycine?
Yes. JECFA number 2122.
How is L-Methionylglycine described, and where does it show up?
Flavorists describe L-Methionylglycine as umami, savory, meaty, broth. It is used in seasoning, sauces, snacks and meat products.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as L-METHIONYLGLYCINE under CAS 14486-03-4 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.