Flavor ingredient regulatory record
L-Ornithine monochlorohydrate
L-Ornithine monochlorohydrate is an amino acid in the savory family, FEMA GRAS under FEMA number 4190 (CAS 3184-13-2). Its odor is umami, savory, meaty, slightly sweet.
- FEMA
- 4190
- CAS
- 3184-13-2
- JECFA
- 2120
- Formula
- C5H13ClN2O2
- EC
- 221-678-6
GRAS status: FEMA GRAS, publication 22. Recorded by FDA in the Substances Added to Food inventory under CAS 3184-13-2.
Structure
Identity
Also known as: L-Ornithine, hydrochloride (1:1), Ornithine, monohydrochloride, L-, L-Ornithine, monohydrochloride, L-Ornithine hydrochloride, Ornithine hydrochloride, Ornithine monohydrochloride, L-(+)-Ornithine monohydrochloride, (S)-2,5-Diaminopentanoic acid hydrochloride, l-ornithine hydrochloride, l-ornithine monohydrochloride, l-ornithine, monohydrochloride, ornithine hydrochloride.
Can L-Ornithine monochlorohydrate be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
L-Ornithine monochlorohydrate is FEMA GRAS under FEMA number 4190. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for L-Ornithine monochlorohydrate. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2120.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. L-Ornithine monochlorohydrate appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 3184-13-2, where EPA names it L-Ornithine, hydrochloride (1:1).
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Umami, savory, meaty, slightly sweet.
Where it is used
L-Ornithine monochlorohydrate is used in nutritional supplements, savory snacks, meat flavoring and sports nutrition, typically as a savory note.
More amino acids in this index
Leucine · L-Isoleucine · L-Glutamine · L-Methionylglycine · L-Alanyl-L-Glutamine · DL-Phenylalanine
L-Ornithine monochlorohydrate FAQ
Is L-Ornithine monochlorohydrate on the FEMA GRAS list?
It is. FEMA number 4190 covers L-Ornithine monochlorohydrate. It is also codified at 21 CFR 172.515.
What is the FEMA number for L-Ornithine monochlorohydrate?
The FEMA number for L-Ornithine monochlorohydrate is 4190 and its CAS registry number is 3184-13-2. FEMA files it in the savory flavor category.
Is L-Ornithine monochlorohydrate approved in the EU?
No EU FL number is on file for L-Ornithine monochlorohydrate. It has a JECFA evaluation (JECFA 2120), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated L-Ornithine monochlorohydrate?
Yes. JECFA number 2120.
What is L-Ornithine monochlorohydrate used for?
L-Ornithine monochlorohydrate is described as umami, savory, meaty, slightly sweet. It shows up in nutritional supplements, savory snacks, meat flavoring and sports nutrition.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as L-ORNITHINE MONOCHLOROHYDRATE/ORNITHINE under CAS 3184-13-2 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.